CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032857
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-CoA synthetase, PfACS12 
Protein Synonyms/Alias
  
Gene Name
 PfACS12 
Gene Synonyms/Alias
 PFF0945c 
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
632YFVNNFLKTDTGKISacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1392 AA 
Protein Sequence
MNQTNSLKSF LNIENVSDRF VTDLNTYKKQ FSYNELYEEI EKFVNFFESI NIKRGDEISI 60
ILFNSIEYII SFLSINFNHN ICLPQNTNLK KEEYKRYLVN NCKYIIIHDY DENNEEYSSI 120
KNKHSYYKNV CIYIKELAEE YGIGLIKIKK NKEKPYFTYS YINNGRKEEL PNLNNDLKNE 180
ENNINKEEKN MLNSDICLHL HTSGTTSKVK IVQLSNTNIK TTITNITNSY NINRDDNTII 240
VMPLFHVHGL IGVLLPIIYC KGNILFQLGH SFSASEFWNN VENYNITYFS AIPTILKILI 300
IRYEEDYLRK NKIKKNNDDD HDDDENNKCH KNPMNEKVKH KLRFIRTSSS SLDENLEKEI 360
EEKFEVSVFQ AYGMTEACHQ VSSNKIIISS LSSPNNLQIC KKFKSVGIPN VGVIIYNEEK 420
KKICDYNELG EICINGKNVM CGYKELKDND NIYIYANTVK ERNEYMMKNP FLEIAEKVPF 480
FKTGDIGYID QDNFLFISGR IKDIINRGGE KIIPNEIDDV LRNHDLVQDC LTFSCKDDVY 540
GEIINSAVIL EENKILSSYN DDYNKNNTNN IYINKSSHEQ KNMSLSPFDE NLSIYLNLKY 600
YMLKKELINY MKKYIADFKV PRNIYFVNNF LKTDTGKISR KKVSESIEEL KKKQIKVFDN 660
IIPLIFKKYD IKYIYGLYGI PINKIIYSFI KNNIYYISFR NEINASISCN YINYFDINNK 720
EEKNKIGILF TCSGPAFINT LSGLYNAKVN NLPMVLICFE NVRNEKLTLF EKYCNFQYFP 780
QLDFLNKTKE ICNQTYHVNN TLESFSTQFF NCIYTSLQHK APTYLNIDYK LIEQTITLDK 840
AIETLQLCDI YAQKCLNPNQ FNKYTLLNNE QENLFTQLLN KFLQIYKNNQ KCVIFMGINC 900
NYGYKYIIKL AELLKIPIYT NTMAKSFVKE NYLYNMNSCK SYLFNNLDSC ICIGSVFNFY 960
FNFGNFPNCQ KKNMLCIDLI NNAYDHDDQH HNNNNNNDNN NNNKGDTLDV SHYFFSDLFH 1020
ILKKLYYSVK NVIHIDDIEN KKEWVNILNE MKKTNFNKMC IQINKYFEEE QFTMEQAMLI 1080
IRHILIDYYF LKNDIDEENK KHFLNYLKHV DKIKIRDFTN MQNVQYNDLM DKELDIPDVD 1140
EDILSDHNND HNNDHNSGHN NNNDTHIHQY QDYSYNVYEK KDIIPKRKKK ELYFLKKQIK 1200
NRIIITNEGS ITLNLGILYL PKFGPYSYVI PQINGMMGVS MNASISAALD NPNNIIFSIL 1260
GDSSFGFTSN EIETICRLKL KIVFIIFNNN GIYGNRDIPR EQNETNTCIK EKHQTNNPSY 1320
YLNNPSSLYF FSKYENYVIA HGGYGCYIDN RKDFIKQMKY VTSQDFDHYP ALLNVIIEDS 1380
GFVNFDVDKF VK 1392 
Gene Ontology
 GO:0005324; F:long-chain fatty acid transporter activity; ISS:GeneDB_Pfalciparum.
 GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006097; P:glyoxylate cycle; ISS:GeneDB_Pfalciparum.
 GO:0001676; P:long-chain fatty acid metabolic process; IEA:GOC. 
Interpro
 IPR000873; AMP-dep_Synth/Lig.
 IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
 IPR000399; TPP-bd_CS.
 IPR011766; TPP_enzyme-bd_C. 
Pfam
 PF00501; AMP-binding
 PF02775; TPP_enzyme_C
 PF02776; TPP_enzyme_N 
SMART
  
PROSITE
 PS00187; TPP_ENZYMES 
PRINTS