CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase TAO3 
Protein Synonyms/Alias
 Thousand and one amino acid protein 3 
Gene Name
 Taok3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
284IRRERPPKVLIDLIQubiquitination[1]
830QHERELQKLEQRVSLacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity). 
Sequence Annotation
 DOMAIN 24 277 Protein kinase.
 NP_BIND 30 38 ATP (By similarity).
 ACT_SITE 147 147 Proton acceptor (By similarity).
 BINDING 53 53 ATP (By similarity).
 MOD_RES 324 324 Phosphoserine; by ATM (Probable).
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 442 442 Phosphoserine (By similarity).  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA repair; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 898 AA 
Protein Sequence
MRKGALKDPE IADLFFKDDP EELFIDLHEI GHGSFGAVYF ATNAHTNEVV AVKKMSYSGK 60
QTHEKWQDIL KEVKFLQQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120
EVEIAAITHG ALQGLAYLHF HSLIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180
TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT 240
LQSREWTDSF RRFVDYCLHK IPQERPAAVE LLRHDFIRRE RPPKVLIDLI QRTKDAVREL 300
DNLQYRKMKK ILFQETRNGP LNESQEEEED GEQGSNLNRE VDSLGSIHSI PSTSVSTGSR 360
SSSVNSMQEV MDESSSELVM MQEDEGTANS SASTVHKKDH VFVRDEAGHG DPRPEPRPTQ 420
SVQSRALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN 480
KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVATIE KEAKVAAADE KKFQQQILAQ 540
QKKDLTTFLE SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL 600
LTQQRLYYDR NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE 660
YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK 720
KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KAILKTLKDE QTRKLAILAE QYEQSINEMM 780
ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA 840
HLEQKIEEEL AALQKERSER IKTLLERQER ETETFDMESL RMGFGNLVTL DFPKEDYR 898 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0031572; P:G2 DNA damage checkpoint; ISS:UniProtKB.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
 GO:0046330; P:positive regulation of JNK cascade; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
 GO:0046777; P:protein autophosphorylation; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS