CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DET1 homolog 
Protein Synonyms/Alias
 De-etiolated-1 homolog 
Gene Name
 DET1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
437RQIQRRFKDTIINAKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Nucleus; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MVGQILKRDV IMDHHVSTIK PRRIQNQNVI HRLERRRISS GKAGTHWHQV RVFHQNVFPN 60
FTVVNVEKPP CFLRKFSPDG RYFIAFSSDQ TSLEIYEYQG CQAAEDLLQG YEGEILSNGN 120
DQRSVNIRGR LFERFFVLLH ITNVAANGEH LNRECSLFTD DCRCVIVGSA AYLPDEPHPP 180
FFEVYRNSES VTPNPRSPLE DYSLHIIDLH TGRLCDTRTF KCDKVVLSHN QGLYLYKNIL 240
AILSVQQQTI HVFQVTPEGT FIDVRTIGRF CYEDDLLTVS AVFPEVQRDS QTGMANPFRD 300
PFINSLKHRL LVYLWRRAEQ DGSAMAKRRF FQYFDQLRQL RMWKMQLLDE NHLFIKYTSE 360
DVVTLRVTDP SQASFFVVYN MVTTEVIAVF ENTSDELLEL FENFCDLFRN ATLHSEVQFP 420
CSASSNNFAR QIQRRFKDTI INAKYGGHTE AVRRLLGQLP ISAQSYSGSP YLDLSLFSYD 480
DKWVSVMERP KTCGDHPIRF YARDSGLLKF EIQAGLLGRP INHTVRRLVA FTFHPFEPFA 540
ISVQRTNAEY VVNFHMRHCC T 561 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR019138; De-etiolated_protein_1_Det1. 
Pfam
 PF09737; Det1 
SMART
  
PROSITE
  
PRINTS