UniProt Accession

 F16P1_HUMAN; P09467; O75571; Q53F94; Q96E46 

Genbank Protein ID

 M19922; L10320; D26054; D26055; D26056; U21931; U21925; U21926; U21927; U21929; U21930; AF073475; AK223395; AY866483; AL161728; BC012927; U47919; U47918 

Genbank Nucleotide ID

 AAA35517.1; AAA35817.1; BAA05051.1; BAA05052.1; BAA05053.1; AAC50207.1; AAC50207.1; AAC50207.1; AAC50207.1; AAC50207.1; AAC50207.1; AAC25774.1; BAD97115.1; AAW34363.1; CAH72692.1; AAH12927.1; AAA89098.1; AAA89097.1 

Protein Name

 Fructose-1,6-bisphosphatase 1 

Protein Synonyms/Alias

 FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 

Gene Name

 FBP1 

Gene Synonyms/Alias

 FBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
330	DDVLEFLKVYEKHSA	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

  

Sequence Annotation

 NP_BIND 18 22 AMP.
 NP_BIND 28 32 AMP.
 NP_BIND 113 114 AMP.
 REGION 122 125 Substrate binding.
 REGION 213 216 Substrate binding.
 REGION 244 249 Substrate binding.
 REGION 275 277 Substrate binding.
 METAL 69 69 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 2.
 METAL 119 119 Magnesium 2.
 METAL 119 119 Magnesium 3.
 METAL 121 121 Magnesium 2; via carbonyl oxygen.
 METAL 122 122 Magnesium 3.
 METAL 281 281 Magnesium 3.
 BINDING 141 141 AMP.
 BINDING 265 265 Substrate.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; Allosteric enzyme; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Gluconeogenesis; Hydrolase; Magnesium; Metal-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0016208; F:AMP binding; IDA:UniProtKB.
 GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IMP:UniProtKB.
 GO:0048029; F:monosaccharide binding; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0071286; P:cellular response to magnesium ion; IDA:UniProtKB.
 GO:0006002; P:fructose 6-phosphate metabolic process; IDA:UniProtKB.
 GO:0006000; P:fructose metabolic process; TAS:ProtInc.
 GO:0006094; P:gluconeogenesis; IMP:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0045820; P:negative regulation of glycolysis; IDA:UniProtKB.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0006111; P:regulation of gluconeogenesis; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000146; FBPase_class-1/SBPase.
 IPR020548; Fructose_bisphosphatase_AS. 

Pfam

 PF00316; FBPase 

SMART

  

PROSITE

 PS00124; FBPASE 

PRINTS

 PR00115; F16BPHPHTASE.