CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037483
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable leucine--tRNA ligase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 LARS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
285LHGHSSLKEALRMALacetylation[1]
386AFLALTQKARGKRVGubiquitination[2]
402DVTSDKLKDWLISRQubiquitination[2]
557LLAQGLIKGQTFRLPubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 860 AA 
Protein Sequence
MASVWQRLGF YASLLKRQLN GGPDVIKWER RVIPGCTRSI YSATGKWTKE YTLQTRKDVE 60
KWWHQRIKEQ ASKISEADVI NPMGWDAFGL PAENAAVERN LHPQSWTQSN IKHMRKQLDR 120
LGLCFSWDRE ITTCLPDYYK WTQYLFIKLY EAGLAYQKEA LVNWDPVDQT VLANEQVDEH 180
GCSWRSGAKV EQKYLRQWFI KTTAYAKAMQ DALADLPEWY GIKGMQAHWI GDCVGCHLDF 240
TLKVHGQATG EKLTAYTATP EAIYGTSHVA ISPSHRLLHG HSSLKEALRM ALVPGKDCLT 300
PVMAVNMLTQ QEVPVVILAK ADLEGSLDSK IGIPSTSSED TILAQTLGLA YSEVIETLPD 360
GTERLSSSAE FTGMTRQDAF LALTQKARGK RVGGDVTSDK LKDWLISRQR YWGTPIPIVH 420
CPVCGPTPVP LEDLPVTLPN IASFTGKGGP PLAMASEWVN CSCPRCKGAA KRETDTMDTF 480
VDSAWYYFRY TDPHNPHSPF NTAVADYWMP VDLYIGGKEH AVMHLFYARF FSHFCHDQKM 540
VKHREPFHKL LAQGLIKGQT FRLPSGQYLQ REEVDLTGSV PVHAKTKEKL EVTWEKMSKS 600
KHNGVDPEEV VEQYGIDTIR LYILFAAPPE KDILWDVKTD ALPGVLRWQQ RLWTLTTRFI 660
EARASGKSPQ PQLLSNKEKA EARKLWEYKN SVISQVTTHF TEDFSLNSAI SQLMGLSNAL 720
SQASQSVILH SPEFEDALCA LMVMAAPLAP HVTSEIWAGL ALVPRKLCAH YTWDASVLLQ 780
AWPAVDPEFL QQPEVVQMAV LINNKACGKI PVPQQVARDQ DKVHEFVLQS ELGVRLLQGR 840
SIKKSFLSPR TALINFLVQD 860 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004823; F:leucine-tRNA ligase activity; IEA:InterPro.
 GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
 GO:0006450; P:regulation of translational fidelity; IEA:GOC. 
Interpro
 IPR002300; aa-tRNA-synth_Ia.
 IPR002302; Leu-tRNA-ligase_bac/mito.
 IPR014729; Rossmann-like_a/b/a_fold.
 IPR009080; tRNAsynth_1a_anticodon-bd.
 IPR013155; V/L/I-tRNA-synth_anticodon-bd.
 IPR009008; Val/Leu/Ile-tRNA-synth_edit. 
Pfam
 PF08264; Anticodon_1
 PF00133; tRNA-synt_1 
SMART
  
PROSITE
  
PRINTS
 PR00985; TRNASYNTHLEU.