UniProt Accession

 H0Y455_HUMAN; H0Y455 

Genbank Protein ID

 AL136233 

Genbank Nucleotide ID

  

Protein Name

 DNA replication ATP-dependent helicase/nuclease DNA2 

Protein Synonyms/Alias

  

Gene Name

 DNA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	LLKLAKFKIGFLRLG	ubiquitination	[1]
26	LRLGQIQKVHPAIQQ	ubiquitination	[1]
133	GMSESLFKRLEQNKS	ubiquitination	[1, 2]
154	VQYRMNSKIMSLSNK	ubiquitination	[1]
167	NKLTYEGKLECGSDK	ubiquitination	[1, 2]
174	KLECGSDKVANAVIN	ubiquitination	[1, 2]
230	PAPEQVEKGGVSNVT	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
 GO:0043142; F:single-stranded DNA-dependent ATPase activity; IEA:InterPro.
 GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro. 

Interpro

 IPR026851; Dna2.
 IPR027417; P-loop_NTPase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS