UniProt Accession

 SPYA_RAT; P09139; Q9R2C7 

Genbank Protein ID

 X06357; D13667; M35270 

Genbank Nucleotide ID

 CAA29656.1; BAA02838.1; AAA42169.1 

Protein Name

 Serine--pyruvate aminotransferase, mitochondrial 

Protein Synonyms/Alias

 SPT; Alanine--glyoxylate aminotransferase; AGT 

Gene Name

 Agxt 

Gene Synonyms/Alias

 Agt1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
38	PPPEALSKPLSIPKR	acetylation	[1]
44	SKPLSIPKRLLLGPG	acetylation	[1]
73	RMIGHMQKEMFQIMD	acetylation	[1]
247	SLISFNDKAKSKVYS	acetylation	[1]
258	KVYSRKTKPVSFYTD	acetylation	[1]
330	CLRELGLKFFVKDPE	acetylation	[1]
334	LGLKFFVKDPEIRLP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). 

Sequence Annotation

 MOTIF 412 414 Microbody targeting signal (By
 BINDING 382 382 Substrate (By similarity).
 MOD_RES 231 231 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Alternative initiation; Aminotransferase; Complete proteome; Direct protein sequencing; Mitochondrion; Peroxisome; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IDA:HGNC.
 GO:0005782; C:peroxisomal matrix; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0008453; F:alanine-glyoxylate transaminase activity; IDA:RGD.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:Compara.
 GO:0004760; F:serine-pyruvate transaminase activity; IDA:RGD.
 GO:0019265; P:glycine biosynthetic process, by transamination of glyoxylate; IDA:RGD.
 GO:0009436; P:glyoxylate catabolic process; IEA:Compara.
 GO:0042853; P:L-alanine catabolic process; IEA:Compara.
 GO:0019448; P:L-cysteine catabolic process; IEA:Compara.
 GO:0046724; P:oxalic acid secretion; IEA:Compara.
 GO:0006625; P:protein targeting to peroxisome; IEA:Compara.
 GO:0042866; P:pyruvate biosynthetic process; IDA:RGD.
 GO:0051591; P:response to cAMP; IDA:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IDA:RGD. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR020578; Aminotrans_V_PyrdxlP_BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR024169; SP_NH2Trfase/AEP_transaminase. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

 PS00595; AA_TRANSFER_CLASS_5 

PRINTS