CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030504
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 E3 ubiquitin-protein ligase RNF13 
Protein Synonyms/Alias
 Ring finger protein 13, isoform CRA_a; cDNA FLJ33452 fis, clone BRAMY2000151, highly similar to RING finger protein 13 
Gene Name
 RNF13 
Gene Synonyms/Alias
 hCG_21342 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
113KLPVHKFKKGDEYDVubiquitination[1]
114LPVHKFKKGDEYDVCubiquitination[1, 2, 3, 4]
154CVDPWLTKTKKTCPVubiquitination[1, 3, 4]
157PWLTKTKKTCPVCKQubiquitination[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
MLILMTSLAW DPTTVSTVEV LKKIDIPSVF IGESSANSLK DEFTYEKGGH LILVPEFSLP 60
LEYYLIPFLI IVGICLILIV IFMITKFVQD RHRARRNRLR KDQLKKLPVH KFKKGDEYDV 120
CAICLDEYED GDKLRILPCS HAYHCKCVDP WLTKTKKTCP VCKQKVVPSQ GDSDSDTDSS 180
QEENEVTEHT PLLRPLASVS AQSFGALSES RSHQNMTESS DYEEDDNEDT DSSDAENEIN 240
EHDVVVQLQP NGERDYNIAN TV 262 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2 
PRINTS