| Tag | Content |
|---|
| CPLM ID | CPLM-014623 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UDP-glucuronosyltransferase 1-6 |
Protein Synonyms/Alias | UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; Phenol UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1A6; UGT1A6; UGP1A1; UGT1A7 |
Gene Name | Ugt1a6 |
Gene Synonyms/Alias | Ugt1; Ugt1a6a; Ugt1a7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 198 | YVPRFYTKFSDHMTF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate. |
Sequence Annotation | CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
CARBOHYD 431 431 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 531 AA |
Protein Sequence | MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS ERGHDIMVLV 60
PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL PGASLMGPLR EYRNNMIVVD 120
MFFSNCQSLL KDSATLSFLR ENKFDALFTD PAMPCGVILA EYLNLPSVYL FRGFPCSLEH 180
MLGQSPSPVS YVPRFYTKFS DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD 240
VSLPSLHQNS LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI 300
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV KWLPQNDLLG 360
HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 420
LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 480
WYQYHSLDVI GFLLAIVLTV VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H 531 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IDA:MGI. GO:0015020; F:glucuronosyltransferase activity; IDA:MGI. GO:0019585; P:glucuronate metabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |