UniProt Accession

 PDXL2_HUMAN; Q9NZ53; Q6UVY4; Q8WUV6 

Genbank Protein ID

 AF219137; AY359096; BC019330; BC052585 

Genbank Nucleotide ID

 AAF44629.1; AAQ89454.1; AAH19330.1; AAH52585.1 

Protein Name

 Podocalyxin-like protein 2 

Protein Synonyms/Alias

 Endoglycan 

Gene Name

 PODXL2 

Gene Synonyms/Alias

 UNQ1861/PRO3742 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
381	DSTQVICKDWSNLAG	ubiquitination	[1]
533	QRRLPKLKHVSHGEE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. 

Sequence Annotation

 REGION 129 134 O-glycosylated at one site.
 MOD_RES 97 97 Sulfotyrosine.
 MOD_RES 118 118 Sulfotyrosine.
 MOD_RES 570 570 Phosphoserine.
 MOD_RES 596 596 Phosphoserine.
 CARBOHYD 144 144 O-linked (GalNAc...).
 CARBOHYD 193 193 N-linked (GlcNAc...) (Potential).
 CARBOHYD 395 395 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sialic acid; Signal; Sulfation; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 605 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005539; F:glycosaminoglycan binding; TAS:ProtInc.
 GO:0050901; P:leukocyte tethering or rolling; IDA:UniProtKB. 

Interpro

 IPR013836; CD34/Podocalyxin. 

Pfam

 PF06365; CD34_antigen 

SMART

  

PROSITE

  

PRINTS