UniProt Accession

 ZN639_HUMAN; Q9UID6; A9X3Z9; D3DNR3 

Genbank Protein ID

 AF003924; AB097862; AC007823; CH471052; CH471052; CH471052; CH471052; BC020500; BC026181; DQ323613 

Genbank Nucleotide ID

 AAF21240.1; BAC77610.1; EAW78413.1; EAW78414.1; EAW78415.1; EAW78416.1; AAH20500.1; AAH26181.1; ABD27860.1 

Protein Name

 Zinc finger protein 639 

Protein Synonyms/Alias

 Zinc finger protein ANC_2H01; Zinc finger protein ZASC1 

Gene Name

 ZNF639 

Gene Synonyms/Alias

 ZASC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
263	EEDPYICKYCDYKTV	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds DNA and may function as a transcriptional repressor. 

Sequence Annotation

 ZN_FING 204 227 C2H2-type 1.
 ZN_FING 233 255 C2H2-type 2.
 ZN_FING 260 283 C2H2-type 3.
 ZN_FING 289 311 C2H2-type 4.
 ZN_FING 374 397 C2H2-type 5.
 ZN_FING 403 425 C2H2-type 6.
 ZN_FING 431 454 C2H2-type 7.
 ZN_FING 460 482 C2H2-type 8.
 REGION 371 455 Interaction with CTNNA2.
 MOD_RES 60 60 Phosphoserine.
 MOD_RES 88 88 Phosphoserine.  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 485 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043922; P:negative regulation by host of viral transcription; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0043923; P:positive regulation by host of viral transcription; IMP:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0046718; P:viral entry into host cell; IDA:UniProtKB. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS