UniProt Accession

 LYS12_YEAST; P40495; D6VVJ3 

Genbank Protein ID

 Z46728; BK006942 

Genbank Nucleotide ID

 CAA86700.1; DAA08459.1 

Protein Name

 Homoisocitrate dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 HIcDH 

Gene Name

 LYS12 

Gene Synonyms/Alias

 LYS10; LYS11; YIL094C; YI9910.02C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	IPGDGIGKEVIPAGK	acetylation	[1]
82	ALPDETVKVLKEQCQ	acetylation	[1]
127	FANVRPVKSVEGEKG	acetylation	[1]
133	VKSVEGEKGKPIDMV	acetylation	[1]
135	SVEGEKGKPIDMVIV	acetylation	[1]
152	NTEDLYIKIEKTYID	acetylation	[1]
155	DLYIKIEKTYIDKAT	acetylation	[1]
160	IEKTYIDKATGTRVA	acetylation	[1]
236	KDKYGQIKYNEQIVD	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. 

Sequence Annotation

 METAL 243 243 Magnesium or manganese (By similarity).
 METAL 267 267 Magnesium or manganese (By similarity).
 METAL 271 271 Magnesium or manganese (By similarity).
 BINDING 114 114 Substrate (By similarity).
 BINDING 124 124 Substrate (By similarity).
 BINDING 143 143 Substrate (By similarity).
 BINDING 243 243 Substrate (By similarity).
 MOD_RES 98 98 Phosphoserine.  

Keyword

 Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; Lysine biosynthesis; Magnesium; Manganese; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0047046; F:homoisocitrate dehydrogenase activity; IDA:SGD.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0009085; P:lysine biosynthetic process; IC:SGD.
 GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IEA:UniProtKB-UniPathway. 

Interpro

 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR001804; Isocitrate/isopropylmalate_DH.
 IPR024084; IsoPropMal-DH-like_dom. 

Pfam

 PF00180; Iso_dh 

SMART

  

PROSITE

 PS00470; IDH_IMDH 

PRINTS