UniProt Accession

 UB2G2_MOUSE; P60605; P56554 

Genbank Protein ID

 AF296657; BC010321 

Genbank Nucleotide ID

 AAK52608.1; AAH10321.1 

Protein Name

 Ubiquitin-conjugating enzyme E2 G2 

Protein Synonyms/Alias

 Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2 

Gene Name

 Ube2g2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
153	DDREQFYKIAKQIVQ	ubiquitination	[1]
156	EQFYKIAKQIVQKSL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) (By similarity). 

Sequence Annotation

 ACT_SITE 89 89 Glycyl thioester intermediate (By  

Keyword

 3D-structure; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0030433; P:ER-associated protein catabolic process; IDA:MGI.
 GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.
 GO:0018279; P:protein N-linked glycosylation via asparagine; ISS:UniProtKB. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS