UniProt Accession

 DHCR7_MOUSE; O88455 

Genbank Protein ID

 AF057368; BC006854 

Genbank Nucleotide ID

 AAC40164.1; AAH06854.1 

Protein Name

 7-dehydrocholesterol reductase 

Protein Synonyms/Alias

 7-DHC reductase; Sterol Delta(7)-reductase 

Gene Name

 Dhcr7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	KVKSPNGKAGSQGQW	ubiquitination	[1]
369	GRCLIWGKKPKAIEC	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC). 

Sequence Annotation

 MOD_RES 14 14 Phosphoserine (By similarity).  

Keyword

 Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 471 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005640; C:nuclear outer membrane; IEA:Compara.
 GO:0047598; F:7-dehydrocholesterol reductase activity; IDA:MGI.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0030154; P:cell differentiation; IMP:MGI.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:0045540; P:regulation of cholesterol biosynthetic process; IEA:Compara.
 GO:0016126; P:sterol biosynthetic process; IMP:MGI. 

Interpro

 IPR001171; Ergosterol_biosynth_ERG4_ERG24.
 IPR018083; Sterol_reductase_CS. 

Pfam

 PF01222; ERG4_ERG24 

SMART

  

PROSITE

 PS01017; STEROL_REDUCT_1
 PS01018; STEROL_REDUCT_2 

PRINTS