UniProt Accession

 SMS2_HUMAN; Q8NHU3; A8K2S9; B2RA61 

Genbank Protein ID

 AF452717; AK290344; AK314049; CH471057; BC028705; BC041369; AC096564 

Genbank Nucleotide ID

 AAP13352.1; BAF83033.1; BAG36758.1; EAX06211.1; AAH28705.1; AAH41369.1 

Protein Name

 Phosphatidylcholine:ceramide cholinephosphotransferase 2 

Protein Synonyms/Alias

 Sphingomyelin synthase 2 

Gene Name

 SGMS2 

Gene Synonyms/Alias

 SMS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	GLRKGTKKYPDYIQI	ubiquitination	[1]
71	MPTESRNKFPLEWWK	ubiquitination	[1]
116	LSPPLPDKFFDYIDR	ubiquitination	[2]
363	KIGEDNEKST*****	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. 

Sequence Annotation

 ACT_SITE 229 229
 ACT_SITE 272 272
 ACT_SITE 276 276
 LIPID 331 331 S-palmitoyl cysteine.
 LIPID 332 332 S-palmitoyl cysteine.
 LIPID 343 343 S-palmitoyl cysteine.
 LIPID 348 348 S-palmitoyl cysteine.  

Keyword

 Cell membrane; Complete proteome; Golgi apparatus; Kinase; Lipid metabolism; Lipoprotein; Membrane; Palmitate; Polymorphism; Reference proteome; Sphingolipid metabolism; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0045203; C:integral to cell outer membrane; IEA:Compara.
 GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0047493; F:ceramide cholinephosphotransferase activity; IDA:UniProtKB.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0033188; F:sphingomyelin synthase activity; IEA:EC.
 GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.
 GO:0006686; P:sphingomyelin biosynthetic process; IDA:UniProtKB. 

Interpro

 IPR025749; Sphingomyelin_synth-like_dom. 

Pfam

 PF14360; PAP2_C 

SMART

  

PROSITE

  

PRINTS