UniProt Accession

 ENSA_RAT; P60841; Q6PCU7; Q9CQZ9; Q9Z0G1 

Genbank Protein ID

 AJ005984; BC059135 

Genbank Nucleotide ID

 CAA06798.1; AAH59135.1 

Protein Name

 Alpha-endosulfine 

Protein Synonyms/Alias

 ARPP-19e 

Gene Name

 Ensa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MSQKQEEENPA	acetylation	[1]
36	PEKAEEAKLKAKYPS	acetylation	[1]
47	KYPSLGQKPGGSDFL	acetylation	[1]
63	KRLQKGQKYFDSGDY	acetylation	[1]
74	SGDYNMAKAKMKNKQ	acetylation	[1]
114	KSSLVTSKLAGGQVE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine; by GWL (By similarity).
 MOD_RES 109 109 Phosphoserine; by PKA (Probable).  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
 GO:0015459; F:potassium channel regulator activity; NAS:RGD.
 GO:0051721; F:protein phosphatase 2A binding; ISS:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0008601; F:protein phosphatase type 2A regulator activity; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
 GO:0007067; P:mitosis; ISS:UniProtKB.
 GO:0009749; P:response to glucose stimulus; IEP:RGD. 

Interpro

 IPR006760; Endosulphine. 

Pfam

 PF04667; Endosulfine 

SMART

  

PROSITE

  

PRINTS