UniProt Accession

 AROK_ECOLI; P0A6D7; P24167; P78113; Q2M755; Q8X4S0 

Genbank Protein ID

 M76389; X80167; L39822; Z19601; U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAC36834.1; CAA56448.1; AAB59099.1; CAA79665.1; AAA58187.1; AAC76415.2; BAE77901.1 

Protein Name

 Shikimate kinase 1 

Protein Synonyms/Alias

 SK 1; Shikimate kinase I; SKI 

Gene Name

 aroK 

Gene Synonyms/Alias

 b3390; JW5947 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
41	DSDQEIEKRTGADVG	acetylation	[1]
65	GFRDREEKVINELTE	acetylation	[1]
73	VINELTEKQGIVLAT	acetylation	[1]
160	RTDDQSAKVVANQII	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. 

Sequence Annotation

 NP_BIND 14 19 ATP (By similarity).
 REGION 116 127 Lid domain.
 METAL 18 18 Magnesium (By similarity).
 BINDING 36 36 Substrate (By similarity).
 BINDING 60 60 Substrate (By similarity).
 BINDING 82 82 Substrate; via amide nitrogen (By
 BINDING 120 120 ATP (By similarity).
 BINDING 140 140 Substrate (By similarity).
 BINDING 157 157 ATP (By similarity).  

Keyword

 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004765; F:shikimate kinase activity; IEA:HAMAP.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:HAMAP.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000623; Shikimate_kinase/TSH1.
 IPR023000; Shikimate_kinase_CS. 

Pfam

 PF01202; SKI 

SMART

  

PROSITE

 PS01128; SHIKIMATE_KINASE 

PRINTS

 PR01100; SHIKIMTKNASE.