CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NLRC5 
Protein Synonyms/Alias
  
Gene Name
 Nlrc5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
720LPTMGSLKTLGLTGSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. 
Sequence Annotation
 DOMAIN 223 542 NACHT.
 REPEAT 622 646 LRR 1.
 REPEAT 716 740 LRR 2.
 REPEAT 744 771 LRR 3.
 REPEAT 772 796 LRR 4.
 REPEAT 871 898 LRR 5.
 REPEAT 900 923 LRR 6.
 REPEAT 930 953 LRR 7.
 REPEAT 1006 1033 LRR 8.
 REPEAT 1034 1055 LRR 9.
 REPEAT 1138 1161 LRR 10.
 REPEAT 1162 1184 LRR 11.
 REPEAT 1240 1263 LRR 12.
 REPEAT 1265 1292 LRR 13.
 REPEAT 1348 1371 LRR 14.
 REPEAT 1481 1504 LRR 15.
 REPEAT 1519 1542 LRR 16.
 REPEAT 1552 1575 LRR 17.
 REPEAT 1576 1598 LRR 18.
 REPEAT 1603 1626 LRR 19.
 REPEAT 1631 1654 LRR 20.
 REPEAT 1659 1682 LRR 21.
 REPEAT 1687 1711 LRR 22.
 REPEAT 1715 1738 LRR 23.
 REPEAT 1741 1768 LRR 24.
 REPEAT 1769 1795 LRR 25.
 REPEAT 1821 1845 LRR 26.
 REPEAT 1849 1872 LRR 27.
 NP_BIND 229 236 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Immunity; Innate immunity; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1915 AA 
Protein Sequence
MDAESIRLNN ENLWAWLVRL LSKNPEWLSA KLRSFLPTMD LDCSYEPSNP EVIHRQLNRL 60
FAQGMATWKS FINDLCFELD VPLDMEIPLV SIWGPRDEFS KQLGAGEESC PGPQLYHGAK 120
RPFQSYGSSP RRKNSKKQQL ELAKKYLKLL KTSAQQWHGG VCPGAWLTPH SPQTYIPPVL 180
QWSRATAPLD AQEGATLGDP EAADNIDVSI QDLFSFKAHK GPRVTVLLGK AGMGKTTLAY 240
RLRWRWAQGQ LDRFQALFLF EFRQLNMITQ LPTLPQLLFD LYLMPESEPD AVFQYLKENA 300
QEVLLIFDGL DEALHADSVG TDNAGSALTL FSELCHGNLL PGCWVMTTSR PGKLPSCVPT 360
EAATVHMWGF DGLRVEKYVT CFFSDLLSQE LALKEMRTNA RLRGMCAIPA LCTVTCFCLR 420
RLLPGSSPGQ SAALLPTITQ LYLQMVETFS PSETLLDTSI LGFGKVALRG LDTGKVVFSV 480
EDISPQLMSF GAVHSLLTSF CIHTRPGHEE IGYAFVHLSL QEFFAALYLM ASHTVDKDTL 540
VEYVTLNSHW VLRTKGRLGL SDHLPAFLAG LASHTCHMFL CQLAQQDRAW VGSRQAAVIQ 600
VLRKLASRKL TGPKMIELYH CVAETQDLEL ARFTAQSLPS RLSFHNFPLT HADLAALANI 660
LEHRDDPIHL DFDGCPLEPH CPEALVGCGQ VENLSFKSRK CGDAFAEALC RSLPTMGSLK 720
TLGLTGSRIT AQGISHLIQT LPLCSQLEEV SLHDNQLKDP EVLSLVELLP SLPKLQKLDL 780
SRNSFSRSIL LSLVKVAITC PTVRKLQVRE LDLIFYLSPV TETATQQSGA SDVQGKDSLK 840
EGQSRSLQLR LQKCQLRIRD AEALVELFQK SPQLEEVNLS GNHLEDDGCR LVAEAASQLH 900
IAQKLDLSDN GLSQTGVTYV LKAMSTCGTL EDLHISLLNN TVVLTFAQEP REQEGSCKGR 960
APLISFVSPV TSELSQRSRR IRLTHCGFLA KHTETLCEAL RASCQTHNLD HLDLSDNSLG 1020
GKGVILLTEL LPGLGPLKSL NLSRNGLSMD AVFSLVQCLS SLQWVFHLDV SLESDCIFLR 1080
GAGTSRDALE PKFQTGVQVL ELSQRYTSRS FCLQECQLEP TSLTFLCATL EKSPGPLEVQ 1140
LSCKSLSDDS LKILLQCLPQ LPQLSLLQLR HTVLSSRSPF LLADIFNLCP RVRKVTLRSL 1200
CHAVLHFDSN EEQEGVCCGF PGCSLSQEHM ETLCCALSKC NALSQLDLTD NLLGDIGLRC 1260
LLECLPQLPI SGWLDLSHNN ISQEGILYLL ETLPSYPNIQ EVSVSLSSEQ IFRMCFSKKE 1320
GAGTSLRLCE CSFSPEQVSK LASSLSQAQQ LTELWLTKCH LDLPQLTMLL NLVNRPTGLL 1380
GLRLEEPWVD SVSLPALMEV CAQASGCLTE LSISEIQRKL WLQLEFPHQE GNSDSMALRL 1440
AHCDLETEHS HLMIQLVETY ARLQQLSLSQ VSFNDNDGTS SKLLQNILLS SCELKSFRLT 1500
FSQVSTKSLT HLAFGLGHCH HLEELDFSNN SLREEDTELL MGALQGTCRL KKLHLSFLPL 1560
GASSLALLIQ GLSRMTLLQD LCLSHNQIGD VGTQCLAAIL PKLPELRKFD LSHNQIGDVG 1620
TQCLAAILPK LPELRKFNLS HNQIGHVGTQ CLAAILPKLP ELRKFDLSRN QIGDVGTQCL 1680
AAILPKLPEL RKFDLSGNRI GPAGGVQLVK SLTHFEHLEE IKLGNNALGE PTALELAQRL 1740
PPQLRVLCLP SSHLGPEGAL GLAQALEQCP HIEEVSLAEN NLAGGVPRFS KRLPLLRQID 1800
LEFCKIEDQA ARHLAANLTL FPALEKLLLS GNLLGDEVAA ELAQVLPQMG QLKKVNLEWN 1860
RITARGAQLL AQGLVQGSCV PVIRLWNNPI LNDVAQSLQS QEPRLDFSIT DQQTL 1915 
Gene Ontology
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051607; P:defense response to virus; ISS:UniProtKB.
 GO:0045087; P:innate immune response; IMP:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IDA:UniProtKB.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; ISS:UniProtKB.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; ISS:UniProtKB. 
Interpro
 IPR000767; Disease_R.
 IPR007111; NACHT_NTPase.
 IPR027417; P-loop_NTPase. 
Pfam
  
SMART
  
PROSITE
 PS51450; LRR
 PS50837; NACHT 
PRINTS
 PR00364; DISEASERSIST.