| Tag | Content |
|---|
| CPLM ID | CPLM-016888 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanine nucleotide-binding protein-like 3 |
Protein Synonyms/Alias | Nucleolar GTP-binding protein 3; Nucleostemin |
Gene Name | Gnl3 |
Gene Synonyms/Alias | Ns |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 362 | DSLHFFTKLAQRRGL | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. |
Sequence Annotation | NP_BIND 176 179 GTP (Potential).
NP_BIND 256 263 GTP (Potential).
NP_BIND 300 303 GTP (Potential).
REGION 2 46 Basic (By similarity).
REGION 277 451 Intermediate (By similarity).
REGION 460 532 Acidic (By similarity).
MOD_RES 79 79 N6-acetyllysine (By similarity).
MOD_RES 505 505 Phosphoserine.
MOD_RES 518 518 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 538 AA |
Protein Sequence | MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV PNSAPFKEAL 60
LREAELRKQQ LEELKQQQKL DRQKEQERKR KLEVSPGDEQ SNVETREESD EPKRKKAKAG 120
KQNPKKLHCQ ELKKVIEASD IVLEVLDARD PLGCRCPQIE EAVIQSGSKK LILVLNKSDL 180
VPKENLENWL NYLNKELPTV VFKASTNLKN RKTFKIKKKK VVPFQSKICC GKEALWKLLG 240
DFQQSCGKDI QVGVIGFPNV GKSSVINSLK QEWICNVGIS MGLTRSMQIV PLDKQITIID 300
SPCLIISPCN SPTALALRSP ASIEELRPLE AASAILSQAD NEQVVLKYTV PEYKDSLHFF 360
TKLAQRRGLH QKGGSPNVES AAKLVWSEWT GASLGYYCHP PASWNHSLHF NENIAAVMKK 420
GFNLEELEKN NAHSIQVLKG PHLTNRILFR SSGLTNGILD EKDIVEESPR QTEDKQDADD 480
QENGSGERNA EISDVAPVEE TRELSPEQST AGKPSDGSSA LDRASQEDET YDFTTDYI 538 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |