CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ral guanine nucleotide dissociation stimulator-like 2 
Protein Synonyms/Alias
 cDNA FLJ53778, highly similar to Ral guanine nucleotide dissociation stimulator-like 2 
Gene Name
 RGL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116QTGYAAGKGVGGGSAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 460 AA 
Protein Sequence
MPPPRSSRRL RAGTLEALVR HLLDTRTSGT DVSFMSAFLA THRAFTSTPA LLGLMADRLE 60
ALESHPTDEL ERTTEVAISV LSTWLASHPE DFGSEAKGQL DRLESFLLQT GYAAGKGVGG 120
GSADLIRNLR SRVDPQAPDL PKPLALPGDP PADPTDVLVF LADHLAEQLT LLDAELFLNL 180
IPSQCLGGLW GHRDRPGHSH LCPSVRATVT QFNKVAGAVV SSVLGATSTG EGPGEVTIRP 240
LRPPQRARLL EKWIRVAEEC RLLRNFSSVY AVVSALQSSP IHRLRAAWGE ATRDSLRVFS 300
SLCQIFSEED NYSQSRELLV QEVKLQSPLE PHSKKAPRSG SRGGGVVPYL GTFLKDLVML 360
DAASKDELEN GYINFDKRRK VSGVSGLDAG LPYPCSRKGR GKSQGSLSFG SCSLRAPSQE 420
FAVLSELRRL QNECRGYNLQ PDHDIQRWLQ GLRPLTEAQR 460 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR000651; Ras-like_Gua-exchang_fac_N.
 IPR019804; Ras_G-nucl-exch_fac_CS.
 IPR008937; Ras_GEF.
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25. 
Pfam
 PF00617; RasGEF
 PF00618; RasGEF_N 
SMART
 SM00147; RasGEF
 SM00229; RasGEFN 
PROSITE
 PS00720; RASGEF
 PS50009; RASGEF_CAT
 PS50212; RASGEF_NTER 
PRINTS