CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039858
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein KIAA1586 
Protein Synonyms/Alias
  
Gene Name
 KIAA1586 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68TENNEVSKNHCRLSKubiquitination[1]
99KPSLSSKKEIDNLVLubiquitination[1]
135KEGKLGCKDCSAVRHubiquitination[1]
169VTPNGSNKTTRQASLubiquitination[1]
191DVSKAHGKIQDLLKEubiquitination[1]
197GKIQDLLKESTNDSIubiquitination[1]
214LVHKQNNKNIDATVKubiquitination[1]
248GARELQEKNGEVNCLubiquitination[1, 2, 3]
408DDSISEIKQINHLKIubiquitination[1, 2, 4]
433QPNKNQTKLLGTVAKubiquitination[1]
440KLLGTVAKELETEIIubiquitination[1]
448ELETEIIKIGRVMGPubiquitination[1]
546NLKIGTGKYESQIEDubiquitination[1]
636FHLCKILKYEVDLNDubiquitination[1]
653EFVNNNIKSNNVSIPubiquitination[1, 2, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 760 AA 
Protein Sequence
MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSILFPK MPKRQGDFLH FLNVKKVKTD 60
TENNEVSKNH CRLSKAKEPH FEYIEQPIIE EKPSLSSKKE IDNLVLPDCW NEKQAFMFTE 120
QYKWLEIKEG KLGCKDCSAV RHLGSKAEKH VHVSKEWIAY LVTPNGSNKT TRQASLRKKI 180
REHDVSKAHG KIQDLLKEST NDSICNLVHK QNNKNIDATV KVFNTVYSLV KHNRPLSDIE 240
GARELQEKNG EVNCLNTRYS ATRIAEHIAK EMKMKIFKNI IEENAKICII IDEASTVSKK 300
TTLVIYLQCT IQSAPAPVML FVALKELVST IAECIVNTLL TTLNDCGFTN EYLKANLIAF 360
CSDGANTILG RKSGVATKLL ENFPEIIIWN CLNHRLQLSL DDSISEIKQI NHLKIFIDKI 420
YSIYHQPNKN QTKLLGTVAK ELETEIIKIG RVMGPRWAAC SLQAATAVWH AYPILYMHFS 480
HSYSGLAKRL ANINFLQDLA LMIDILEEFS VLSTALQSRS TNIKKAQKLI KRTIRALENL 540
KIGTGKYESQ IEDLIKSDKF KDIPFNKNNK FNALPRSILL DNIIQHMNLR LLSDRNHEDI 600
FNYFDLLEPS TWPYEEITSP WIAGEKTLFH LCKILKYEVD LNDFREFVNN NIKSNNVSIP 660
TTIYKAKKIV STIAINSAEA ERGFNLMNII CTRVRNSLTI DHVSDLMTIN LLGKELADWD 720
ATPFVKSWSN CNHRLATDTR VRQKSTKVFH ENQLAIWNLK 760 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR012337; RNaseH-like_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS