UniProt Accession

 MOSC1_HUMAN; Q5VT66; A8K447; B2D078; Q5VVS9; Q5VVT0; Q5VVT1; Q8N9P5; Q96FN8; Q9H6C7 

Genbank Protein ID

 AK026043; AK094105; AK290812; EU563849; AL606726; AL445423; AL445423; AL445423; AL445423; AL606726; CH471100; BC010619 

Genbank Nucleotide ID

 BAB15333.1; BAC04286.1; BAF83501.1; ACB21046.1; CAH71881.1; CAH71881.1; CAH72116.1; CAH72118.1; CAH72119.1; CAH72119.1; EAW93291.1; AAH10619.1 

Protein Name

 MOSC domain-containing protein 1, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial amidoxime reducing component 1; mARC1; Moco sulfurase C-terminal domain-containing protein 1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1 

Gene Name

 MARC1 

Gene Synonyms/Alias

 MOSC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
202	IADLFRPKDQIAYSD	ubiquitination	[1]
312	KEPLETLKSYRQCDP	ubiquitination	[1]
327	SERKLYGKSPLFGQY	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 

Sequence Annotation

 DOMAIN 187 335 MOSC.  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Molybdenum; Oxidoreductase; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0030151; F:molybdenum ion binding; IDA:UniProtKB.
 GO:0043546; F:molybdopterin cofactor binding; IDA:UniProtKB.
 GO:0008940; F:nitrate reductase activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0051410; P:detoxification of nitrogen compound; NAS:UniProtKB.
 GO:0042126; P:nitrate metabolic process; IDA:UniProtKB. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS