UniProt Accession

 GIMA1_HUMAN; Q8WWP7; B2RCI3; Q8NAZ0 

Genbank Protein ID

 AJ306287; AK091818; AK315127; CH471173; BC040736 

Genbank Nucleotide ID

 CAC83740.1; BAC03754.1; BAG37580.1; EAW54095.1; AAH40736.1 

Protein Name

 GTPase IMAP family member 1 

Protein Synonyms/Alias

 Immunity-associated protein 1; hIMAP1 

Gene Name

 GIMAP1 

Gene Synonyms/Alias

 IMAP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MGGRKMATDEEN	ubiquitination	[1]
40	VGRTGAGKSATGNSI	ubiquitination	[1]
75	TGSRRWDKCHVEVVD	ubiquitination	[1, 2]
93	IFSSQVSKTDPGCEE	ubiquitination	[1, 2]
154	MVIVFTRKEDLAGGS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). 

Sequence Annotation

 NP_BIND 34 42 GTP.
 NP_BIND 153 155 GTP.
 BINDING 55 55 GTP (By similarity).
 BINDING 190 190 GTP.  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Golgi apparatus; GTP-binding; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0030217; P:T cell differentiation; IEA:Compara. 

Interpro

 IPR006703; AIG1.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04548; AIG1 

SMART

  

PROSITE

  

PRINTS