UniProt Accession

 AAKB1_MOUSE; Q9R078; Q91YN6 

Genbank Protein ID

 AF108215; BC016398 

Genbank Nucleotide ID

 AAF14222.1; AAH16398.1 

Protein Name

 5'-AMP-activated protein kinase subunit beta-1 

Protein Synonyms/Alias

 AMPK subunit beta-1; AMPKb 

Gene Name

 Prkab1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
72	HDLEANDKAPAQARP	ubiquitination	[1]
201	SKPEERFKAPPILPP	acetylation	[2]
201	SKPEERFKAPPILPP	succinylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). 

Sequence Annotation

 REGION 68 163 Glycogen-binding domain (By similarity).
 MOD_RES 4 4 Phosphothreonine (By similarity).
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 6 6 Phosphoserine (By similarity).
 MOD_RES 19 19 Phosphothreonine (By similarity).
 MOD_RES 24 24 Phosphoserine; by autocatalysis (By
 MOD_RES 25 25 Phosphoserine; by autocatalysis (By
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 96 96 Phosphoserine (By similarity).
 MOD_RES 101 101 Phosphoserine (By similarity).
 MOD_RES 108 108 Phosphoserine; by autocatalysis.
 MOD_RES 148 148 Phosphothreonine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).  

Keyword

 Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lipoprotein; Myristate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 270 AA 

Protein Sequence

Gene Ontology

 GO:0031588; C:AMP-activated protein kinase complex; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0004679; F:AMP-activated protein kinase activity; TAS:MGI.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0050790; P:regulation of catalytic activity; IEA:Compara. 

Interpro

 IPR006828; AMP_prot_kin_bsu_interact-dom. 

Pfam

 PF04739; AMPKBI 

SMART

 SM01010; AMPKBI 

PROSITE

  

PRINTS