UniProt Accession

 F5H241_HUMAN; F5H241 

Genbank Protein ID

 AL713999 

Genbank Nucleotide ID

  

Protein Name

 Glucosylceramidase 

Protein Synonyms/Alias

  

Gene Name

 GBA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	WTSPTWLKTNGAVNG	ubiquitination	[1, 2]
219	LLLPHWAKVVLTDPE	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 423 AA 

Protein Sequence

Gene Ontology

 GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0006665; P:sphingolipid metabolic process; IEA:InterPro. 

Interpro

 IPR013780; Glyco_hydro_13_b.
 IPR001139; Glyco_hydro_30.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 

Pfam

 PF02055; Glyco_hydro_30 

SMART

  

PROSITE

  

PRINTS

 PR00843; GLHYDRLASE30.