CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018547
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beclin-1 
Protein Synonyms/Alias
 Coiled-coil myosin-like BCL2-interacting protein; Protein GT197 
Gene Name
 Becn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
183EQLQRELKELALEEEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity). 
Sequence Annotation
 MOTIF 106 125 BH3 (By similarity).
 MOD_RES 117 117 Phosphothreonine; by DAPK1 (By  
Keyword
 3D-structure; Antiviral defense; Autophagy; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MEGSKASSST MQVSFVCQRC SQPLKLDTSF KILDRVTIQE LTAPLLTTAQ AKPGESQEEE 60
ANSGEEPFIE TRQDGVSRRF IPPARMMSTE SANSFTLIGE ASDGGTMENL SRRLKVTGDL 120
FDIMSGQTDV DHPLCEECTD TLLDQLDTQL NVTENECQNY KRCLEMLEQM NEGDSEQLQR 180
ELKELALEEE RLIQELEDVE KNRKVVAENL EKVQAEAERL DQEEAQYQRE YSEFKRQQLE 240
LDDELKSVEN QMRYAQMQLD KLKKTNVFNA TFHIWHSGQF GTINNFRLGR LPSAPVEWNE 300
INAAWGQTVL LLHALANKMG LKFQRYRLVP YGNHSYLESL TDKSKELPLY CSGGLRFFWD 360
NKFDHAMVAF LDCVQQFKEE VEKGETRFCL PYRMDVEKGK IEDTGGSGGS YSIKTQFNSE 420
EQWTKALKFM LTNLKWGLAW VSSQFYNK 448 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IMP:RGD.
 GO:0050435; P:beta-amyloid metabolic process; IEA:Compara.
 GO:0071275; P:cellular response to aluminum ion; IEP:RGD.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEP:RGD.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0007040; P:lysosome organization; IEA:Compara.
 GO:0060548; P:negative regulation of cell death; IMP:RGD.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0016239; P:positive regulation of macroautophagy; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0033197; P:response to vitamin E; IEP:RGD. 
Interpro
 IPR007243; Beclin_fam. 
Pfam
 PF04111; APG6 
SMART
  
PROSITE
  
PRINTS