CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hyccin 
Protein Synonyms/Alias
 Down-regulated by CTNNB1 protein A; Protein FAM126A 
Gene Name
 FAM126A 
Gene Synonyms/Alias
 DRCTNNB1A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34YATNLKDKSSLVSSLubiquitination[1]
402ETTGESCKDHFARKQubiquitination[1]
424NLELLSLKRLTLTTSubiquitination[1]
503ERTELPMKHQSGQQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May have a role in the beta-catenin/Lef signaling pathway. May have a role in the process of myelination of the central and peripheral nervous system. 
Sequence Annotation
 MOD_RES 453 453 Phosphoserine.  
Keyword
 Alternative splicing; Cataract; Complete proteome; Cytoplasm; Disease mutation; Leukodystrophy; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MFTSEKGVVE EWLSEFKTLP ETSLPNYATN LKDKSSLVSS LYKVIQEPQS ELLEPVCHQL 60
FEFYRSGEEQ LLQFTLQFLP ELIWCYLAVS ASRNVHSSGC IEALLLGVYN LEIVDKQGHT 120
KVLSFTIPSL SKPSVYHEPS SIGSMALTES ALSQHGLSKV VYSGPHPQRE MLTAQNRFEV 180
LTFLLLCYNA ALTYMPSVSL QSLCQICSRI CVCGYPRQHV RKYKGISSRI PVSSGFMVQM 240
LTGIYFAFYN GEWDLAQKAL DDIIYRAQLE LYPEPLLVAN AIKASLPHGP MKSNKEGTRC 300
IQVEITPTSS RISRNAVTSM SIRGHRWKRH GNTELTGQEE LMEISEVDEG FYSRAASSTS 360
QSGLSNSSHN CSNKPSIGKN HRRSGGSKTG GKEKETTGES CKDHFARKQT QRAQSENLEL 420
LSLKRLTLTT SQSLPKPSSH GLAKTAATVF SKSFEQVSGV TVPHNPSSAV GCGAGTDANR 480
FSACSLQEEK LIYVSERTEL PMKHQSGQQR PPSISITLST D 521 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0004871; F:signal transducer activity; NAS:UniProtKB. 
Interpro
 IPR018619; Hyccin. 
Pfam
 PF09790; Hyccin 
SMART
  
PROSITE
  
PRINTS