CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptojanin-1 
Protein Synonyms/Alias
 Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1 
Gene Name
 Synj1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
515TLQSASSKVLKNMCEubiquitination[1]
577GIQEFQDKRSKPTDIubiquitination[1]
659DVAVDTVKTGMGGATubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis. 
Sequence Annotation
 DOMAIN 119 442 SAC.
 DOMAIN 894 971 RRM.
 REPEAT 1401 1403 1.
 REPEAT 1410 1412 2.
 REPEAT 1421 1423 3.
 REGION 500 899 Catalytic (Potential).
 REGION 1401 1423 3 X 3 AA repeats of N-P-F.
 MOD_RES 784 784 Phosphotyrosine (By similarity).
 MOD_RES 786 786 Phosphotyrosine (By similarity).
 MOD_RES 830 830 Phosphoserine (By similarity).
 MOD_RES 1048 1048 Phosphothreonine (By similarity).
 MOD_RES 1053 1053 Phosphoserine (By similarity).
 MOD_RES 1147 1147 Phosphoserine (By similarity).
 MOD_RES 1217 1217 Phosphothreonine (By similarity).
 MOD_RES 1350 1350 Phosphoserine (By similarity).
 MOD_RES 1354 1354 Phosphothreonine (By similarity).
 MOD_RES 1566 1566 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Endocytosis; Hydrolase; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1574 AA 
Protein Sequence
MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYAKVLDAY 60
GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRVDA SDEDRISEVR 120
KVLNSGNFYF AWSASGVSLD LSLNAHRSMQ EHTTDNRFFW NQSLHLHLKH YGVNCDDWLL 180
RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVIYLD 240
DCVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK DLYGKQIVVN 300
LLGSKEGEHM LSKAFQSHLK ASEHASDIHM VSFDYHQMVK GGKAEKLHSV LKPQVQKFLD 360
YGFFYFDGSA VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 420
FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 480
LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKNM CENFYKYSKP KKIRVCVGTW 540
NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 600
VNASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 660
GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFVEIARK LSFPMGRMLF 720
SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQIF RGFLEGKVTF 780
APTYKYDLFS EDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 840
WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQK IYKEVIAVQG PPDGTVLVSI 900
KSSAQENTFF DDALIDELLQ QFAHFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 960
NRTITITLKS PDWIKTLEEE MSLEKISVTL PSSTSSTLLG EDAEVSADFD MEGDVDDYSA 1020
EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTAPEYS APSLPIRPSR APSRTPGPLS 1080
SQGAPVDTQP AAQKESSQTI EPKRPPPPRP VAPPARPAPP QRPPPPSGAR SPAPARKEFG 1140
GVGAPPSPGV TRREMEAPKS PGTARKDNIG RNQPSPQAGL AGPGPSGYGA ARPTIPARAG 1200
VISAPQSQAR VSAGRLTPES QSKPLETSKG PAVLPEPLKP QAAFPPQPSL PTPAQKLQDP 1260
LVPIAAPMPP SIPQSNLETP PLPPPRSRSS QSLPSDSSPQ LQQEQPTGQQ VKINGACGVK 1320
QEPTLKSDPF EDLSLSVLAV SKAQPSAQIS PVLTPDPKML IQLPSASQSK VNSLSSVSCM 1380
LTMPPVPEQS KSQESVGSSA NPFPSLPTRN PFTDRTAAPG NPFRVQSQES EATSWLSKEE 1440
PVSNSPFPPL MPLSHDMSKP SSSLDGFEDN FDLQSQSTVK TSNPKGWVTF DEDEDFPTKG 1500
KSRSVYPDSL GNTAASFDDD WSKGTNVSFC VLPARRPPPP PPPVPLLPPG TTSSAGPSTT 1560
LSSKASPTLD FTER 1574 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0034595; F:phosphatidylinositol phosphate 5-phosphatase activity; IDA:RGD.
 GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0017124; F:SH3 domain binding; IDA:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
 GO:0014015; P:positive regulation of gliogenesis; IMP:RGD.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:RGD.
 GO:0034097; P:response to cytokine stimulus; IMP:RGD.
 GO:0032526; P:response to retinoic acid; IMP:RGD. 
Interpro
 IPR015047; DUF1866.
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR002013; Syja_N. 
Pfam
 PF08952; DUF1866
 PF03372; Exo_endo_phos
 PF02383; Syja_N 
SMART
 SM00128; IPPc 
PROSITE
 PS50102; RRM
 PS50275; SAC 
PRINTS