UniProt Accession

 MASU1_HUMAN; Q96EH3; A4D154 

Genbank Protein ID

 AK316559; AK127742; AC005082; CH236948; CH471073; BC012331 

Genbank Nucleotide ID

 BAG38148.1; BAG54562.1; EAL24258.1; EAW93785.1; AAH12331.1 

Protein Name

 Mitochondrial assembly of ribosomal large subunit protein 1 

Protein Synonyms/Alias

  

Gene Name

 MALSU1 

Gene Synonyms/Alias

 C7orf30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
192	REIYELEKLWTLRSY	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. 

Sequence Annotation

  

Keyword

 Complete proteome; Mitochondrion; Reference proteome; Repressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0070130; P:negative regulation of mitochondrial translation; IDA:UniProtKB.
 GO:0042273; P:ribosomal large subunit biogenesis; IMP:UniProtKB. 

Interpro

 IPR004394; Iojap/RsfS.
 IPR025656; Oligomer_dom. 

Pfam

 PF02410; Oligomerisation 

SMART

  

PROSITE

  

PRINTS