| Tag | Content |
|---|
| CPLM ID | CPLM-012731 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Guanylate kinase |
Protein Synonyms/Alias | GMP kinase |
Gene Name | GUK1 |
Gene Synonyms/Alias | GMK |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | RPGEENGKDYYFVTR | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Essential for recycling GMP and indirectly, cGMP. |
Sequence Annotation | DOMAIN 4 186 Guanylate kinase-like.
NP_BIND 11 18 ATP (By similarity).
ACT_SITE 44 44 By similarity.
ACT_SITE 137 137 By similarity.
ACT_SITE 148 148 By similarity.
BINDING 171 171 ATP (By similarity).
BINDING 172 172 ATP; via carbonyl oxygen (By similarity).
MOD_RES 2 2 N-acetylserine.
MOD_RES 53 53 Phosphotyrosine (By similarity). |
Keyword | Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 197 AA |
Protein Sequence | MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV 60
MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI 120
SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE 180
LKEALSEEIK KAQRTGA 197 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004385; F:guanylate kinase activity; IDA:UniProtKB. GO:0017144; P:drug metabolic process; TAS:Reactome. GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome. GO:0006163; P:purine nucleotide metabolic process; IDA:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |