CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004620
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 X-box-binding protein 1 
Protein Synonyms/Alias
 XBP-1; Tax-responsive element-binding protein 5 
Gene Name
 XBP1 
Gene Synonyms/Alias
 TREB5; XBP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
262RFDHIYTKPLVLEIPubiquitination[1]
281SQANVVVKIEEAPLSsumoylation[2]
302PEFIVSVKEEPVEDDsumoylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] SUMO modification regulates the transcriptional activity of XBP1.
 Chen H, Qi L.
 Biochem J. 2010 Jul 1;429(1):95-102. [PMID: 20408817
Functional Description
 Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'- GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax- responsive element (TRE) of HTLV-I. 
Sequence Annotation
 DOMAIN 70 133 bZIP.
 REGION 72 94 Basic motif (By similarity).
 REGION 98 133 Leucine-zipper (By similarity).  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK 60
RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR 120
EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAAGAGP VVTPPEHLPM 180
DSGGIDSSDS ESDILLGILD NLDPVMFFKC PSPEPASLEE LPEVYPEGPS SLPASLSLSV 240
GTSSAKLEAI NELIRFDHIY TKPLVLEIPS ETESQANVVV KIEEAPLSPS ENDHPEFIVS 300
VKEEPVEDDL VPELGISNLL SSSHCPKPSS CLLDAYSDCG YGGSLSPFSD MSSLLGVNHS 360
WEDTFANELF PQLISV 376 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0060691; P:epithelial cell maturation involved in salivary gland development; IEA:Compara.
 GO:0031017; P:exocrine pancreas development; IEA:Compara.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0060096; P:serotonin secretion, neurotransmission; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR004827; bZIP. 
Pfam
 PF07716; bZIP_2 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS