| Tag | Content |
|---|
| CPLM ID | CPLM-021858 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation of very long chain fatty acids protein 2 |
Protein Synonyms/Alias | 3-keto acyl-CoA synthase Elovl2; ELOVL fatty acid elongase 2; ELOVL FA elongase 2; Very-long-chain 3-oxoacyl-CoA synthase 2 |
Gene Name | Elovl2 |
Gene Synonyms/Alias | Ssc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 289 | VANGMTDKKAQ**** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (n-6 and n-3 C18-, C20- and C22-PUFA). Essential for the formation of C24:5(n-6) up to C30:5(n-6) PUFAs in testis, these fatty acids being indispensable for normal spermatogenesis and fertility. |
Sequence Annotation | MOTIF 289 292 Di-lysine motif (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 292 AA |
Protein Sequence | MEQLKAFDNE VNAFLDNMFG PRDSRVRGWF LLDSYLPTFI LTITYLLSIW LGNKYMKNRP 60
ALSLRGILTL YNLAITLLSA YMLVELILSS WEGGYNLQCQ NLDSAGEGDV RVAKVLWWYY 120
FSKLVEFLDT IFFVLRKKTN QITFLHVYHH ASMFNIWWCV LNWIPCGQSF FGPTLNSFIH 180
ILMYSYYGLS VFPSMHKYLW WKKYLTQAQL VQFVLTITHT LSAVVKPCGF PFGCLIFQSS 240
YMMTLVILFL NFYIQTYRKK PVKKELQEKE VKNGFPKAHL IVANGMTDKK AQ 292 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0009922; F:fatty acid elongase activity; IDA:UniProtKB. GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; IDA:UniProtKB. GO:0042761; P:very long-chain fatty acid biosynthetic process; IDA:UniProtKB. |
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PRINTS | |