UniProt Accession

 CXCR7_HUMAN; P25106; A8K6J4; Q53RV4; Q8NE10; Q92938; Q92986 

Genbank Protein ID

 M64749; U73141; U67784; AF030297; DQ822477; AK291659; AC079611; CH471063; BC036661 

Genbank Nucleotide ID

 AAA62370.1; AAB18130.1; AAB16913.1; AAB94130.1; ABH01258.1; BAF84348.1; AAX93086.1; EAW71092.1; AAH36661.1 

Protein Name

 C-X-C chemokine receptor type 7 

Protein Synonyms/Alias

 CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1 

Gene Name

 CXCR7 

Gene Synonyms/Alias

 CMKOR1; GPR159; RDC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
328	NYRYELMKAFIFKYS	ubiquitination	[1, 2, 3]
337	FIFKYSAKTGLTKLI	ubiquitination	[3]
342	SAKTGLTKLIDASRV	ubiquitination	[3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. 

Sequence Annotation

 CARBOHYD 13 13 N-linked (GlcNAc...) (Potential).
 CARBOHYD 22 22 N-linked (GlcNAc...) (Potential).
 CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
 DISULFID 117 196 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Cytoplasm; Developmental protein; Disulfide bond; Endosome; G-protein coupled receptor; Glycoprotein; Host-virus interaction; Membrane; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
 GO:0016494; F:C-X-C chemokine receptor activity; IMP:BHF-UCL.
 GO:0015026; F:coreceptor activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0006935; P:chemotaxis; IEA:InterPro.
 GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.
 GO:0001570; P:vasculogenesis; IEA:InterPro.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR001416; Chemokine_CXCR7.
 IPR000355; Chemokine_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00646; RDC1ORPHANR.