UniProt Accession

 COG8_HUMAN; Q96MW5; Q0VAK2; Q8WVV6; Q9H6F8 

Genbank Protein ID

 AK056344; AK025968; CH471092; BC017492; BC121022; BC121023 

Genbank Nucleotide ID

 BAB71157.1; BAB15301.1; EAW83266.1; AAH17492.1; AAI21023.1; AAI21024.1 

Protein Name

 Conserved oligomeric Golgi complex subunit 8 

Protein Synonyms/Alias

 COG complex subunit 8; Component of oligomeric Golgi complex 8 

Gene Name

 COG8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	DLAFANYKTFIRGAE	ubiquitination	[1, 2, 3]
130	QSCRNFVKEAEEISS	ubiquitination	[1, 3]
246	TEAELRVKFLQARDA	ubiquitination	[3]
273	DPYFHITKTIEASRV	ubiquitination	[1, 3]
381	VAISTFQKAIQETVE	ubiquitination	[1]
558	PLAFILPKRETLFTL	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for normal Golgi function (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 612 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR007255; COG8.
 IPR016632; COG8_Metazoal_Plant.
 IPR016159; Cullin_repeat-like_dom. 

Pfam

 PF04124; Dor1 

SMART

  

PROSITE

  

PRINTS