CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008018
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 12 kDa FK506-binding protein 
Protein Synonyms/Alias
 FKBP; Macrolide-binding protein; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase 
Gene Name
 FK506-bp2 
Gene Synonyms/Alias
 FKBP12; CG11001 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
45DSSRDRNKPFKFTIGacetylation[1]
48RDRNKPFKFTIGKGEacetylation[1]
53PFKFTIGKGEVIRGWacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands. 
Sequence Annotation
 DOMAIN 20 108 PPIase FKBP-type.  
Keyword
 Complete proteome; Cytoplasm; Isomerase; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 108 AA 
Protein Sequence
MGVQVVPIAP GDGSTYPKNG QKVTVHYTGT LDDGTKFDSS RDRNKPFKFT IGKGEVIRGW 60
DEGVAQLSVG QRAKLICSPD YAYGSRGHPG VIPPNSTLTF DVELLKVE 108 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. 
Interpro
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 
Pfam
 PF00254; FKBP_C 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS