| Tag | Content |
|---|
| CPLM ID | CPLM-002605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acetolactate synthase isozyme 1 large subunit |
Protein Synonyms/Alias | AHAS-I; Acetohydroxy-acid synthase I large subunit; ALS-I |
Gene Name | ilvB |
Gene Synonyms/Alias | b3671; JW3646 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | PVWIDIPKDVQTAVF | acetylation | [1] | | 293 | FDDRAIGKTEQFCPN | acetylation | [1] | | 302 | EQFCPNAKIIHVDID | acetylation | [1] | | 315 | IDRAELGKIKQPHVA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | |
Sequence Annotation | NP_BIND 264 285 FAD (By similarity).
NP_BIND 307 326 FAD (By similarity).
REGION 393 473 Thiamine pyrophosphate binding.
METAL 444 444 Magnesium (By similarity).
METAL 471 471 Magnesium (By similarity).
BINDING 60 60 Thiamine pyrophosphate (By similarity).
BINDING 162 162 FAD (By similarity). |
Keyword | Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; FAD; Flavoprotein; Magnesium; Metal-binding; Reference proteome; Thiamine pyrophosphate; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 562 AA |
Protein Sequence | MASSGTTSTR KRFTGAEFIV HFLEQQGIKI VTGIPGGSIL PVYDALSQST QIRHILARHE 60
QGAGFIAQGM ARTDGKPAVC MACSGPGATN LVTAIADARL DSIPLICITG QVPASMIGTD 120
AFQEVDTYGI SIPITKHNYL VRHIEELPQV MSDAFRIAQS GRPGPVWIDI PKDVQTAVFE 180
IETQPAMAEK AAAPAFSEES IRDAAAMINA AKRPVLYLGG GVINAPARVR ELAEKAQLPT 240
TMTLMALGML PKAHPLSLGM LGMHGVRSTN YILQEADLLI VLGARFDDRA IGKTEQFCPN 300
AKIIHVDIDR AELGKIKQPH VAIQADVDDV LAQLIPLVEA QPRAEWHQLV ADLQREFPCP 360
IPKACDPLSH YGLINAVAAC VDDNAIITTD VGQHQMWTAQ AYPLNRPRQW LTSGGLGTMG 420
FGLPAAIGAA LANPDRKVLC FSGDGSLMMN IQEMATASEN QLDVKIILMN NEALGLVHQQ 480
QSLFYEQGVF AATYPGKINF MQIAAGFGLE TCDLNNEADP QASLQEIINR PGPALIHVRI 540
DAEEKVYPMV PPGAANTEMV GE 562 |
Gene Ontology | GO:0005948; C:acetolactate synthase complex; IDA:EcoCyc. GO:0003984; F:acetolactate synthase activity; IDA:EcoCyc. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro. GO:0004802; F:transketolase activity; IDA:EcoCyc. GO:0009097; P:isoleucine biosynthetic process; IDA:EcoCyc. GO:0009099; P:valine biosynthetic process; IDA:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |