CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045210
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sentrin-specific protease 1 
Protein Synonyms/Alias
  
Gene Name
 Senp1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
386LRRIEEQKALALQLQacetylation[1]
418HLRVPLEKEIPVTAAacetylation[1, 2, 3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 666 AA 
Protein Sequence
MDDTADGVKM DAGEVTLVNH GSTFRTHRPP QSGFPEEQLL LSDQQSLPFR QGTLDGSFTC 60
STRSPAYRPD YHSDNPSSDS FLGSGDVRTF GQSANGQWRN STPASGSAPQ KPRNSRSLCL 120
ETRKTSSGLS NTFVGKSNHH CHMSAYEKSF PIKPAPSPSW SGSCRRSLLS PKKTQRRHFS 180
TAEETVQEEE KEIYRQLLQM VTGKQFCVAK PTTHFPLRLS RCLSSNKNSL KDSLLRNGNS 240
CASHVIGSDT SSSGSASILT AQEQLSHSAH SLSSGTPDVA FGSKDSDPHH HLAAPHQPNS 300
LPASNTQSEG SDSVILLKVK ESQTPASRYL SPLKRRSCPY IIPYSAVMDL LSSSPTFFQA 360
ELWIKELTSV YDSRARERLR RIEEQKALAL QLQNQRLQEQ EHAVLDSVEL HLRVPLEKEI 420
PVTAAQETRK KSHQLTDSED EFPEITEEME KEIKNVFRNG NQDEVLSEAF RLTITRKDIQ 480
TLNHLNWLND EIINFYMNML MERSKEKGFP SVHAFNTFFF TKLKTAGYQA VKRWTKKVDV 540
FSVDILLVPI HLGVHWCLAV VDFRRKSITY YDSMGGINNE ACRILLQYLK QESVDKKRKE 600
FDTNGWQLFS KKSQEIPQQM NGSDCGMFAC KYADCITKDR PINFTQQHMP YFRKRMVWEI 660
LHRKLL 666 
Gene Ontology
 GO:0016929; F:SUMO-specific protease activity; IDA:MGI.
 GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0016926; P:protein desumoylation; IDA:MGI.
 GO:0006508; P:proteolysis; IEA:InterPro.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IMP:MGI. 
Interpro
 IPR003653; Peptidase_C48. 
Pfam
 PF02902; Peptidase_C48 
SMART
  
PROSITE
 PS50600; ULP_PROTEASE 
PRINTS