UniProt Accession

 GDIR_YEAST; Q12434; D6VRL3 

Genbank Protein ID

 D31630; X96876; Z74183; AY558165; BK006938 

Genbank Nucleotide ID

 BAA06499.1; CAA65624.1; CAA98708.1; AAS56491.1; DAA11723.1 

Protein Name

 Rho GDP-dissociation inhibitor 

Protein Synonyms/Alias

 Rho GDI 

Gene Name

 RDI1 

Gene Synonyms/Alias

 YDL135C; D2175 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
26	QYKVSAKKTVDEYKN	ubiquitination	[1]
32	KKTVDEYKNLDAEDE	ubiquitination	[2]
93	LTNEKTIKELASKRY	ubiquitination	[2]
131	LRYVQYIKKAGIAVD	acetylation	[3]
181	GNYSAVSKFIDDDKT	acetylation	[3]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 

Sequence Annotation

 MOD_RES 27 27 Phosphothreonine.
 MOD_RES 40 40 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; GTPase activation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 202 AA 

Protein Sequence

Gene Ontology

 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005094; F:Rho GDP-dissociation inhibitor activity; IDA:SGD.
 GO:0007015; P:actin filament organization; IMP:SGD.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0032889; P:regulation of vacuole fusion, non-autophagic; IDA:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IPI:SGD. 

Interpro

 IPR014756; Ig_E-set.
 IPR000406; Rho_GDI.
 IPR024792; RhoGDI_domain. 

Pfam

 PF02115; Rho_GDI 

SMART

  

PROSITE

  

PRINTS

 PR00492; RHOGDI.