UniProt Accession

 ORN_HUMAN; Q9Y3B8; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7 

Genbank Protein ID

 AF151872; AL110239; CR533500; AK223200; BC105024; BC105026; BC107887 

Genbank Nucleotide ID

 AAD34109.1; CAB53690.1; CAG38531.1; BAD96920.1; AAI05025.1; AAI05027.1; AAI07888.1 

Protein Name

 Oligoribonuclease, mitochondrial 

Protein Synonyms/Alias

 RNA exonuclease 2 homolog; Small fragment nuclease 

Gene Name

 REXO2 

Gene Synonyms/Alias

 SFN; SMFN; CGI-114 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	IIDVSTVKELCRRWY	ubiquitination	[1, 2]
190	EYEFAPKKAASHRAL	ubiquitination	[2]
205	DDISESIKELQFYRN	ubiquitination	[1, 2, 3]
234	IENGENEKTVS****	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily

Sequence Annotation

 DOMAIN 43 207 Exonuclease.
 ACT_SITE 164 164 Potential.
 MOD_RES 122 122 Phosphotyrosine.
 MOD_RES 184 184 Phosphotyrosine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Exonuclease; Hydrolase; Manganese; Mitochondrion; Nuclease; Nucleus; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008408; F:3'-5' exonuclease activity; IDA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0009117; P:nucleotide metabolic process; TAS:ProtInc. 

Interpro

 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR022894; Oligoribonuclease.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF00929; RNase_T 

SMART

 SM00479; EXOIII 

PROSITE

  

PRINTS