| Tag | Content |
|---|
| CPLM ID | CPLM-017375 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 18 |
Protein Synonyms/Alias | MacGAP; Rho-type GTPase-activating protein 18 |
Gene Name | ARHGAP18 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 303 | RIPLIFQKLISRIEE | ubiquitination | [1] | | 427 | IDNKEKNKMTVMNVA | ubiquitination | [1] | | 450 | MCHALGLKSSEQREF | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). |
Sequence Annotation | DOMAIN 324 523 Rho-GAP. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 663 AA |
Protein Sequence | MNQESTTIKV MEKPPFDRSI SQDSLDELSM EDYWIELENI KKSSENSQED QEVVVVKEPD 60
EGELEEEWLK EAGLSNLFGE SAGDPQESIV FLSTLTRTQA AAVQKRVETV SQTLRKKNKQ 120
YQIPDVRDIF AQQRESKETA PGGTESQSLR TNENKYQGRD DEASNLVGEE KLIPPEETPA 180
PETDINLEVS FAEQALNQKE SSKEKIQKSK GDDATLPSFR LPKDKTGTTR IGDLAPQDMK 240
KVCHLALIEL TALYDVLGIE LKQQKAVKIK TKDSGLFCVP LTALLEQDQR KVPGMRIPLI 300
FQKLISRIEE RGLETEGLLR IPGAAIRIKN LCQELEAKFY EGTFNWESVK QHDAASLLKL 360
FIRELPQPLL SVEYLKAFQA VQNLPTKKQQ LQALNLLVIL LPDANRDTLK ALLEFLQRVI 420
DNKEKNKMTV MNVAMVMAPN LFMCHALGLK SSEQREFVMA AGTANTMHLL IKYQKLLWTI 480
PKFIVNQVRK QNTENHKKDK RAMKKLLKKM AYDREKYEKQ DKSTNDADVP QGVIRVQAPH 540
LSKVSMAIQL TEELKASDVL ARFLSQESGV AQTLKKGEVF LYEIGGNIGE RCLDDDTYMK 600
DLYQLNPNAE WVIKSKPL 618 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |