| Tag | Content |
|---|
| CPLM ID | CPLM-001653 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polypyrimidine tract-binding protein 3 |
Protein Synonyms/Alias | Regulator of differentiation 1; Rod1 |
Gene Name | PTBP3 |
Gene Synonyms/Alias | ROD1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 14 | DLITVGLKRGSDELL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). |
Sequence Annotation | DOMAIN 59 143 RRM 1.
DOMAIN 182 258 RRM 2.
DOMAIN 358 432 RRM 3.
DOMAIN 475 550 RRM 4.
MOD_RES 423 423 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Differentiation; Erythrocyte maturation; mRNA processing; mRNA splicing; Reference proteome; Repeat; Repressor; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 552 AA |
Protein Sequence | MDGVVTDLIT VGLKRGSDEL LSSGIINGPF TMNSSTPSTG VYANGNDSKK FKRDRPPCSP 60
SRVLHLRKIP CDVTEAEIIS LGLPFGKVTN LLMLKGKSQA FLEMASEEAA VTMVNYYTPI 120
TPHLRSQPVY IQYSNHRELK TDNLPNQARA QAALQAVSAV QSGSLALSGG PSNEGTVLPG 180
QSPVLRIIIE NLFYPVTLEV LHQIFSKFGT VLKIITFTKN NQFQALLQYA DPVNAHYAKM 240
ALDGQNIYNA CCTLRIDFSK LTSLNVKYNN DKSRDFTRLD LPTGDGQPSL EPPMAAAFGA 300
PGIISSPYAG AAGFAPAIGF PQATGLSVPA VPGALGPLTI TSSAVTGRMA IPGASGIPGN 360
SVLLVTNLNP DLITPHGLFI LFGVYGDVHR VKIMFNKKEN ALVQMADANQ AQLAMNHLSG 420
QRLYGKVLRA TLSKHQAVQL PREGQEDQGL TKDFSNSPLH RFKKPGSKNF QNIFPPSATL 480
HLSNIPPSVT VDDLKNLFIE AGCSVKAFKF FQKDRKMALI QLGSVEEAIQ ALIELHNHDL 540
GENHHLRVSF SKSTI 555 |
Gene Ontology | GO:0005634; C:nucleus; IEA:InterPro. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003723; F:RNA binding; TAS:ProtInc. GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc. GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-KW. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0033119; P:negative regulation of RNA splicing; IDA:UniProtKB. GO:0045595; P:regulation of cell differentiation; IEA:Compara. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |