UniProt Accession

 CCND1_MOUSE; P25322 

Genbank Protein ID

 M64403; S78355; BC044841 

Genbank Nucleotide ID

 AAA37502.1; AAB34495.1; AAH44841.1 

Protein Name

 G1/S-specific cyclin-D1 

Protein Synonyms/Alias

  

Gene Name

 Ccnd1 

Gene Synonyms/Alias

 Cyl-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
46	APSVSYFKCVQKEIV	ubiquitination	[1]
238	HFLSRVIKCDPDCLR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). 

Sequence Annotation

 DOMAIN 28 152 Cyclin N-terminal.
 MOD_RES 286 286 Phosphothreonine.
 CROSSLNK 269 269 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Cell cycle; Cell division; Complete proteome; Cyclin; Cytoplasm; Isopeptide bond; Membrane; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:MGI.
 GO:0004672; F:protein kinase activity; IDA:MGI.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:MGI.
 GO:0045444; P:fat cell differentiation; IDA:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO:0033598; P:mammary gland epithelial cell proliferation; IGI:MGI.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; ISS:UniProtKB.
 GO:0030857; P:negative regulation of epithelial cell differentiation; IGI:MGI.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IMP:MGI.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; ISS:UniProtKB.
 GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IGI:MGI.
 GO:0000320; P:re-entry into mitotic cell cycle; IDA:MGI.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0010039; P:response to iron ion; IEA:Compara.
 GO:0032026; P:response to magnesium ion; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara.
 GO:0070141; P:response to UV-A; ISS:UniProtKB.
 GO:0033197; P:response to vitamin E; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara. 

Interpro

 IPR013763; Cyclin-like.
 IPR014400; Cyclin_A/B/D/E.
 IPR004367; Cyclin_C-dom.
 IPR006671; Cyclin_N. 

Pfam

 PF02984; Cyclin_C
 PF00134; Cyclin_N 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00292; CYCLINS 

PRINTS