CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012758
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial inner membrane protein 
Protein Synonyms/Alias
 Cell proliferation-inducing gene 4/52 protein; Mitofilin; p87/89 
Gene Name
 IMMT 
Gene Synonyms/Alias
 HMP; MINOS2; PIG4; PIG52 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84KTIPYSDKLFEMVLGubiquitination[1]
110SIQSGPLKISSVSEVubiquitination[1]
258NSEIAGEKKSAQWRTubiquitination[1]
412NRELAEQKATEKQHIubiquitination[1]
495RVQEQELKSEFEQNLubiquitination[1]
505FEQNLSEKLSEQELQubiquitination[1]
554VAEEEARKAHQLWLSubiquitination[1]
570EALKYSMKTSSAETPubiquitination[1]
629ARFYAVQKLARRVAMubiquitination[1]
703AKFVNQLKGESRRVAubiquitination[1]
715RVAQDWLKEARMTLEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 MOD_RES 211 211 N6-acetyllysine.
 MOD_RES 222 222 N6-acetyllysine.
 MOD_RES 451 451 N6-acetyllysine.
 MOD_RES 506 506 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 758 AA 
Protein Sequence
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG 60
TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE 120
SKQPASQLQK QKGDTPASAT AGDTLSVPAP AVQPEESLKT DHPEIGEGKP TPALSEEASS 180
SSIRERPPEE VAARLAQQEK QEQVKIESLA KSLEDALRQT ASVTLQAIAA QNAAVQAVNA 240
HSNILKAAMD NSEIAGEKKS AQWRTVEGAL KERRKAVDEA ADALLKAKEE LEKMKSVIEN 300
AKKKEVAGAK PHITAAEGKL HNMIVDLDNV VKKVQAAQSE AKVVSQYHEL VVQARDDFKR 360
ELDSITPEVL PGWKGMSVSD LADKLSTDDL NSLIAHAHRR IDQLNRELAE QKATEKQHIT 420
LALEKQKLEE KRAFDSAVAK ALEHHRSEIQ AEQDRKIEEV RDAMENEMRT QLRRQAAAHT 480
DHLRDVLRVQ EQELKSEFEQ NLSEKLSEQE LQFRRLSQEQ VDNFTLDINT AYARLRGIEQ 540
AVQSHAVAEE EARKAHQLWL SVEALKYSMK TSSAETPTIP LGSAVEAIKA NCSDNEFTQA 600
LTAAIPPESL TRGVYSEETL RARFYAVQKL ARRVAMIDET RNSLYQYFLS YLQSLLLFPP 660
QQLKPPPELC PEDINTFKLL SYASYCIEHG DLELAAKFVN QLKGESRRVA QDWLKEARMT 720
LETKQIVEIL TAYASAVGIG TTQVQPE 747 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
 GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:Compara.
 GO:0009409; P:response to cold; IEA:Compara. 
Interpro
 IPR019133; Mt-IM_prot_Mitofilin. 
Pfam
 PF09731; Mitofilin 
SMART
  
PROSITE
  
PRINTS