CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010384
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Lon protease 
Protein Synonyms/Alias
 ATP-dependent protease La 
Gene Name
 lon 
Gene Synonyms/Alias
 MPN_332; MP504 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
130TENKALDKLLERIFPacetylation[1]
772RYLDEVPKDIVKDLEacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). 
Sequence Annotation
 DOMAIN 9 206 Lon.
 NP_BIND 379 386 ATP (By similarity).
 ACT_SITE 702 702 By similarity.
 ACT_SITE 745 745 By similarity.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Hydrolase; Nucleotide-binding; Protease; Reference proteome; Serine protease; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 795 AA 
Protein Sequence
MPAVKKPQIL VVRNQVIFPY NGFELDVGRE RSKKLIKALK NLKTKRLVLV TQKNSDQLNP 60
EFDDIYHCGT LCDIDEIIEV PSEDGKTADY KIKGKGLQRV AITSFSDADL TKYDHHFLNS 120
TLTENKALDK LLERIFPDKE DFAEILDSLN SFLELQELKK LSKVPKDIKR YDIITFKLAS 180
LIFKDITLQQ AILEENDIEK RLQKIIGSGI EDLGHISEEA RAKQRESEFD KIDNRITRKV 240
NEQLSRQQRD FYLREKLRVI REEIGMTSKK EDEVSNIRKK LEENPYPEHI KKRILSELDH 300
FENSSSSSQE STLTKTYIDT LMNLPWWQES KDNADVKNLI KILNKNHSGL DKVKERVVEY 360
LAVQLRTKKL KGPIMCLVGP PGVGKSSLAK SIAEALNKCF VKVSLGGVHD ESEIRGHRKT 420
YLGSMPGRIL KGMVRAKVIN PLFLLDEIDK MTSSNQGYPS GALLEVLDPE LNNKFSDNYV 480
EEDYDLSKVM FVATANYIED IPEALLDRME VIELTSYTEQ EKLQITKSHL VKRCLDDAEI 540
KTDDLKFTDE GISYIIKFYT REAGVRQLER LIQQIVRKYI VNLQKTGEQQ VVVDVDLVKK 600
YLKKEIFDYT VRDEDALPGI VNGMAYTPTG GDLLPIEVTH VAGKGDLILT GNLKQTMRES 660
ASVALGYVKA NAQSFNINPN LFKKVDINIH VPGGGIPKDG PSAGAALVTA IISSLTGKKV 720
DPKIAMTGEI TLRGKVMTIG GVKEKTISAY RGGVRTIFMP EKNERYLDEV PKDIVKDLEI 780
ILVKEYKDIY NKIFN 795 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004176; F:ATP-dependent peptidase activity; IEA:HAMAP.
 GO:0043565; F:sequence-specific DNA binding; IEA:HAMAP.
 GO:0004252; F:serine-type endopeptidase activity; IEA:HAMAP.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0033554; P:cellular response to stress; IEA:HAMAP.
 GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IEA:HAMAP. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR027543; Lon_bac.
 IPR004815; Lon_bac/euk-typ.
 IPR027065; Lon_Prtase.
 IPR027417; P-loop_NTPase.
 IPR008269; Pept_S16_C.
 IPR003111; Pept_S16_N.
 IPR008268; Peptidase_S16_AS.
 IPR015947; PUA-like_domain.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF00004; AAA
 PF02190; LON
 PF05362; Lon_C 
SMART
 SM00382; AAA
 SM00464; LON 
PROSITE
 PS01046; LON_SER 
PRINTS