CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006806
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-synuclein 
Protein Synonyms/Alias
 Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP 
Gene Name
 SNCA 
Gene Synonyms/Alias
 NACP; PARK1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96AAATGFVKKDQLGKNsumoylation[1, 2]
102VKKDQLGKNEEGAPQsumoylation[1, 2]
Reference
 [1] Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein.
 Dorval V, Fraser PE.
 J Biol Chem. 2006 Apr 14;281(15):9919-24. [PMID: 16464864]
 [2] Sumoylation inhibits alpha-synuclein aggregation and toxicity.
 Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kügler S, Melchior F, Bähr M, Weishaupt JH.
 J Cell Biol. 2011 Jul 11;194(1):49-60. [PMID: 21746851] 
Functional Description
 May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. 
Sequence Annotation
 REPEAT 20 30 1.
 REPEAT 31 41 2.
 REPEAT 42 56 3; approximate.
 REPEAT 57 67 4.
 REGION 20 67 4 X 11 AA tandem repeats of [EGS]-K-T-K-
 METAL 2 2 Copper (Probable).
 METAL 50 50 Copper (Probable).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 87 87 Phosphoserine; by CK2.
 MOD_RES 125 125 Phosphotyrosine; by FYN.
 MOD_RES 129 129 Phosphoserine; by BARK1, CK2 and GRK5;
 MOD_RES 129 129 Phosphoserine; by PLK2; alternate.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Alzheimer disease; Amyloid; Cell junction; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Disease mutation; Membrane; Metal-binding; Neurodegeneration; Nucleus; Parkinson disease; Parkinsonism; Phosphoprotein; Reference proteome; Repeat; Synapse; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 140 AA 
Protein Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK 60
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP 120
DNEAYEMPSE EGYQDYEPEA 140 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.
 GO:0030424; C:axon; IDA:UniProtKB.
 GO:0005938; C:cell cortex; IDA:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:Compara.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0043205; C:fibril; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030426; C:growth cone; IDA:UniProtKB.
 GO:0016234; C:inclusion body; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005640; C:nuclear outer membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005840; C:ribosome; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0043195; C:terminal bouton; IEA:Compara.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0005507; F:copper ion binding; IDA:UniProtKB.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.
 GO:0008198; F:ferrous iron binding; IDA:UniProtKB.
 GO:0042393; F:histone binding; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0051219; F:phosphoprotein binding; IDA:BHF-UCL.
 GO:0048156; F:tau protein binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0048148; P:behavioral response to cocaine; IEA:Compara.
 GO:0071280; P:cellular response to copper ion; IDA:UniProtKB.
 GO:0071872; P:cellular response to epinephrine stimulus; TAS:UniProtKB.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; TAS:UniProtKB.
 GO:0051583; P:dopamine uptake involved in synaptic transmission; TAS:UniProtKB.
 GO:0043206; P:extracellular fibril organization; TAS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0001774; P:microglial cell activation; IEA:Compara.
 GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Compara.
 GO:0007006; P:mitochondrial membrane organization; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0045963; P:negative regulation of dopamine metabolic process; IEA:Compara.
 GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IDA:UniProtKB.
 GO:0045920; P:negative regulation of exocytosis; IMP:UniProtKB.
 GO:0035067; P:negative regulation of histone acetylation; IDA:UniProtKB.
 GO:0031115; P:negative regulation of microtubule polymerization; IDA:BHF-UCL.
 GO:0032769; P:negative regulation of monooxygenase activity; IDA:BHF-UCL.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0051622; P:negative regulation of norepinephrine uptake; IDA:UniProtKB.
 GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IDA:UniProtKB.
 GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara.
 GO:0051612; P:negative regulation of serotonin uptake; IDA:UniProtKB.
 GO:0070495; P:negative regulation of thrombin receptor signaling pathway; IDA:UniProtKB.
 GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.
 GO:0006638; P:neutral lipid metabolic process; IEA:Compara.
 GO:0006644; P:phospholipid metabolic process; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IDA:UniProtKB.
 GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:UniProtKB.
 GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISS:BHF-UCL.
 GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:BHF-UCL.
 GO:0001921; P:positive regulation of receptor recycling; IDA:UniProtKB.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
 GO:0031648; P:protein destabilization; IDA:UniProtKB.
 GO:0031623; P:receptor internalization; IDA:UniProtKB.
 GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Compara.
 GO:0014059; P:regulation of dopamine secretion; TAS:UniProtKB.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0014048; P:regulation of glutamate secretion; IEA:Compara.
 GO:0040012; P:regulation of locomotion; IEA:Compara.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0043030; P:regulation of macrophage activation; IEA:Compara.
 GO:0010517; P:regulation of phospholipase activity; IDA:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
 GO:0070555; P:response to interleukin-1; IDA:UniProtKB.
 GO:0010040; P:response to iron(II) ion; IDA:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IDA:UniProtKB.
 GO:0032026; P:response to magnesium ion; IDA:UniProtKB.
 GO:0050808; P:synapse organization; IEA:Compara.
 GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB. 
Interpro
 IPR001058; Synuclein.
 IPR002460; Synuclein_alpha. 
Pfam
 PF01387; Synuclein 
SMART
  
PROSITE
  
PRINTS
 PR01212; ASYNUCLEIN.
 PR01211; SYNUCLEIN.