CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 878 
Protein Synonyms/Alias
  
Gene Name
 ZNF878 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
352VKAFSFVKDLRIHERacetylation[1]
365ERTHTGEKPFECKQCubiquitination[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 4 90 KRAB.
 ZN_FING 122 137 C2H2-type 1; degenerate.
 ZN_FING 143 165 C2H2-type 2.
 ZN_FING 171 193 C2H2-type 3.
 ZN_FING 199 221 C2H2-type 4.
 ZN_FING 227 249 C2H2-type 5.
 ZN_FING 255 277 C2H2-type 6.
 ZN_FING 283 305 C2H2-type 7.
 ZN_FING 311 333 C2H2-type 8.
 ZN_FING 339 361 C2H2-type 9.
 ZN_FING 367 389 C2H2-type 10.
 ZN_FING 395 417 C2H2-type 11.
 ZN_FING 423 445 C2H2-type 12.
 ZN_FING 451 473 C2H2-type 13.
 ZN_FING 479 501 C2H2-type 14.
 ZN_FING 507 529 C2H2-type 15.  
Keyword
 Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ YIEDEHQNPR 60
RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ SYESSVCGEI GIGLSSLNRH 120
LRAFSYSSSL AIHGRTHTGE KPYECKECGK AFRFPSSVRR HERIHSAKKP YECKQCGKAF 180
SFPSSVRRHE RIHSAKKPYE CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS 240
SLKRHEKSHT GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV 300
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF VKDLRIHERT 360
HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC GKAFRSASVL QKHIRTHTGE 420
KPYGCKQCGK VFRVASQLKM HERTHTGEKP YECKQCGKAF ISSNSIRYHK RTHTGEKPYK 480
CKQCGKAFIS SNSFLYHERI HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G 531 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS