UniProt Accession

 A2AIM4_MOUSE; A2AIM4 

Genbank Protein ID

 AL732506 

Genbank Nucleotide ID

  

Protein Name

 Tropomyosin beta chain 

Protein Synonyms/Alias

  

Gene Name

 Tpm2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MDAIKKKMQMLKLD	ubiquitination	[1]
12	KKKMQMLKLDKENAI	ubiquitination	[1]
15	MQMLKLDKENAIDRA	acetylation	[2]
30	EQAEADKKQAEDRCK	ubiquitination	[1]
37	KQAEDRCKQLEEEQQ	ubiquitination	[1]
48	EEQQALQKKLKGTED	acetylation	[2]
48	EEQQALQKKLKGTED	ubiquitination	[1]
51	QALQKKLKGTEDEVE	ubiquitination	[1]
59	GTEDEVEKYSESVKD	acetylation	[2]
59	GTEDEVEKYSESVKD	ubiquitination	[1]
65	EKYSESVKDAQEKLE	ubiquitination	[1]
70	SVKDAQEKLEQAEKK	ubiquitination	[1]
77	KLEQAEKKATDAEAD	ubiquitination	[1]
112	RLATALQKLEEAEKA	acetylation	[2, 3, 4]
112	RLATALQKLEEAEKA	ubiquitination	[1]
118	QKLEEAEKAADESER	acetylation	[2]
118	QKLEEAEKAADESER	ubiquitination	[1]
128	DESERGMKVIENRAM	ubiquitination	[1]
136	VIENRAMKDEEKMEL	acetylation	[2]
140	RAMKDEEKMELQEMQ	acetylation	[2]
149	ELQEMQLKEAKHIAE	acetylation	[2]
149	ELQEMQLKEAKHIAE	ubiquitination	[1]
152	EMQLKEAKHIAEDSD	acetylation	[2]
161	IAEDSDRKYEEVARK	acetylation	[2]
168	KYEEVARKLVILEGE	acetylation	[2]
168	KYEEVARKLVILEGE	ubiquitination	[1]
205	RTMDQALKSLIASEE	ubiquitination	[1]
217	SEEEYSTKEDKYEEE	ubiquitination	[1]
220	EYSTKEDKYEEEIKL	acetylation	[2]
220	EYSTKEDKYEEEIKL	ubiquitination	[1]
226	DKYEEEIKLLEEKLK	acetylation	[2]
226	DKYEEEIKLLEEKLK	ubiquitination	[1]
231	EIKLLEEKLKEAETR	ubiquitination	[1]
233	KLLEEKLKEAETRAE	ubiquitination	[1]
248	FAERSVAKLEKTIDD	acetylation	[2]
251	RSVAKLEKTIDDLED	acetylation	[2]
251	RSVAKLEKTIDDLED	ubiquitination	[1]
264	EDEVYAQKMKYKAIS	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0006936; P:muscle contraction; TAS:MGI. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.