UniProt Accession

 B4DIV9_HUMAN; B4DIV9 

Genbank Protein ID

 AL031685; AL162615; AK295803 

Genbank Nucleotide ID

 BAG58621.1 

Protein Name

 Sodium/hydrogen exchanger 8 

Protein Synonyms/Alias

 cDNA FLJ61281, highly similar to Sodium/hydrogen exchanger 8 

Gene Name

 SLC9A8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
256	HHGRIQMKTLTNKWY	ubiquitination	[1, 2]
261	QMKTLTNKWYEEVRQ	ubiquitination	[1, 3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015386; F:potassium:hydrogen antiporter activity; IEA:Compara.
 GO:0015385; F:sodium:hydrogen antiporter activity; IEA:Compara.
 GO:0051453; P:regulation of intracellular pH; IEA:Compara. 

Interpro

 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR018409; Na/H_exchanger_8_eu. 

Pfam

 PF00999; Na_H_Exchanger 

SMART

  

PROSITE

  

PRINTS