CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004954
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amine oxidase [flavin-containing] A 
Protein Synonyms/Alias
 Monoamine oxidase type A; MAO-A 
Gene Name
 Maoa 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
284LTAKIHFKPELPPERubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. 
Sequence Annotation
 REGION 520 522 Interaction with membrane phospholipid
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 406 406 S-8alpha-FAD cysteine.  
Keyword
 3D-structure; Acetylation; Catecholamine metabolism; Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MTDLEKPNLA GHMFDVGLIG GGISGLAAAK LLSEYKINVL VLEARDRVGG RTYTVRNEHV 60
KWVDVGGAYV GPTQNRILRL SKELGIETYK VNVNERLVQY VKGKTYPFRG AFPPVWNPLA 120
YLDYNNLWRT MDEMGKEIPV DAPWQARHAQ EWDKMTMKDL IDKICWTKTA REFAYLFVNI 180
NVTSEPHEVS ALWFLWYVRQ CGGTARIFSV TNGGQERKFV GGSGQVSEQI MGLLGDKVKL 240
SSPVTYIDQT DDNIIVETLN HEHYECKYVI SAIPPILTAK IHFKPELPPE RNQLIQRLPM 300
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APIAITLDDT KPDGSLPAIM GFILARKADR 360
QAKLHKDIRK RKICELYAKV LGSQEALYPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG 420
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKVAKKD IWVEEPESKD 480
VPAIEITHTF LERNLPSVPG LLKITGVSTS VALLCFVLYK IKKLPC 526 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IDA:RGD.
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:RGD.
 GO:0008131; F:primary amine oxidase activity; IDA:RGD.
 GO:0051378; F:serotonin binding; IDA:RGD.
 GO:0042424; P:catecholamine catabolic process; NAS:RGD.
 GO:0042135; P:neurotransmitter catabolic process; IEA:UniProtKB-KW.
 GO:0042443; P:phenylethylamine metabolic process; IDA:RGD.
 GO:0042428; P:serotonin metabolic process; IDA:RGD. 
Interpro
 IPR002937; Amino_oxidase.
 IPR001613; Flavin_amine_oxidase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01593; Amino_oxidase 
SMART
  
PROSITE
  
PRINTS
 PR00757; AMINEOXDASEF.