CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033378
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sprouty-related, EVH1 domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 SPRED2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
271SSYVRFAKGEVPKHDubiquitination[1]
304GRGGSVIKTQPSRGKubiquitination[1, 2, 3]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 433 AA 
Protein Sequence
MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG GGISRVGVCK 60
VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN PTFHHWKVDN RKFGLTFQSP 120
ADARAFDRGV RKAIEDLIEG STTSSSTIHN EAELGDDDVF TTATDSSSNS SQKREQPTRT 180
ISSPTSCEHR RIYTLGHLHD SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM 240
TGYEDYRHAP VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG 300
SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT CIRRVSCMWC 360
ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS FLAPCMCCYL PLRACYHCGV 420
MCRCCGGKHK AAA 433 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0009966; P:regulation of signal transduction; IEA:InterPro. 
Interpro
 IPR000697; EVH1.
 IPR023337; KBD.
 IPR011993; PH_like_dom.
 IPR007875; Sprouty. 
Pfam
 PF05210; Sprouty
 PF00568; WH1 
SMART
  
PROSITE
 PS51488; KBD
 PS51227; SPR
 PS50229; WH1 
PRINTS